Charles J. Russell, Ph.D.

Associate Member (St. Jude faculty)
Department of Infectious Diseases
St. Jude Children's Research Hospital

Assistant Professor (affiliate)
Department of Microbiology, Immunology & Biochemistry
University of Tennessee Health Sciences Center

Office: 262 DANNY THOMAS PL, MS 330 MEMPHIS TN 381053678
Tel: (901) 595-5648
crusse15@uthsc.edu
CharlesRussell.html

Education

  • PostDoc, HHMI at Northwestern University, Evanston, IL, Virology
  • Ph.D., University of California at Berkeley, Chemistry
  • Fulbright Scholar, University of Duisburg, Germany, Theoretical Chemistry
  • B.S., Millikin University, Decatur, IL, Chemistry

Research Interest/Specialty

  • Molecular mechanisms of infectious diseases caused by emerging influenza viruses and paramyxoviruses
  • Negative-strand RNA virus replication and pathogenesis, focusing on influenza viruses and paramyxoviruses
  • Viral envelope glycoproteins as targets for novel vaccines and drugs

Publications

  1. DuBois, RM, Zaraket, H, Reddivari, M, Heath, RJ, White, SW, Russell, CJ. Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity. PLoS Pathog, 7 (12), e1002398, 2011.
  2. Russell, CJ. Stalking influenza diversity with a universal antibody. N Engl J Med, 365 (16), 1541-2, 2011.
  3. Burke, CW, Mason, JN, Surman, SL, Jones, BG, Dalloneau, E, Hurwitz, JL, Russell, CJ. Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy. PLoS Pathog, 7 (7), e1002134, 2011.
  4. Marcelin, G, DuBois, R, Rubrum, A, Russell, CJ, McElhaney, JE, Webby, RJ. A contributing role for anti-neuraminidase antibodies on immunity to pandemic H1N1 2009 influenza A virus. PLoS One, 6 (10), e26335, 2011.
  5. DuBois, RM, Aguilar-Yañez, JM, Mendoza-Ochoa, GI, Oropeza-Almazán, Y, Schultz-Cherry, S, Alvarez, MM, White, SW, Russell, CJ. The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunogenic structure. J Virol, 85 (2), 865-72, 2011.
  6. Reed, ML, Bridges, OA, Seiler, P, Kim, JK, Yen, HL, Salomon, R, Govorkova, EA, Webster, RG, Russell, CJ. The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks. J Virol, 84 (3), 1527-35, 2010.
  7. Luque, LE, Bridges, OA, Mason, JN, Boyd, KL, Portner, A, Russell, CJ. Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice. J Virol, 84 (2), 810-21, 2010.
  8. Watanabe, M, Mishin, VP, Brown, SA, Russell, CJ, Boyd, K, Babu, YS, Taylor, G, Xiong, X, Yan, X, Portner, A, Alymova, IV. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob Agents Chemother, 53 (9), 3942-51, 2009.
  9. Boyd, VA, Mason, J, Hanumesh, P, Price, J, Russell, CJ, Webb, TR. 2-Substituted-4,5-dihydroxypyrimidine-6-carboxamide antiviral targeted libraries. J Comb Chem, 11 (6), 1100-4, 2009.
  10. Reed, ML, Yen, HL, DuBois, RM, Bridges, OA, Salomon, R, Webster, RG, Russell, CJ. Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein. J Virol, 83 (8), 3568-80, 2009.
  11. Jones, B, Zhan, X, Mishin, V, Slobod, KS, Surman, S, Russell, CJ, Portner, A, Hurwitz, JL. Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV. Vaccine, 27 (12), 1848-57, 2009.
  12. Zhan, X, Slobod, KS, Krishnamurthy, S, Luque, LE, Takimoto, T, Jones, B, Surman, S, Russell, CJ, Portner, A, Hurwitz, JL. Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections. Vaccine, 26 (27-28), 3480-8, 2008.
  13. Luque, LE, Russell, CJ. Spring-loaded heptad repeat residues regulate the expression and activation of paramyxovirus fusion protein. J Virol, 81 (7), 3130-41, 2007.
  14. Ilyushina, NA, Govorkova, EA, Russell, CJ, Hoffmann, E, Webster, RG. Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus. J Gen Virol, 88 (Pt 4), 1266-74, 2007.
  15. Russell, CJ, Luque, LE. The structural basis of paramyxovirus invasion. Trends Microbiol, 14 (6), 243-6, 2006.
  16. Russell, CJ, Webster, RG. The genesis of a pandemic influenza virus. Cell, 123 (3), 368-71, 2005.
  17. Russell, CJ, Jardetzky, TS, Lamb, RA. Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state. J Virol, 78 (24), 13727-42, 2004.
  18. Waning, DL, Russell, CJ, Jardetzky, TS, Lamb, RA. Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail. Proc Natl Acad Sci U S A, 101 (25), 9217-22, 2004.
  19. Takeda, M, Leser, GP, Russell, CJ, Lamb, RA. Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci U S A, 100 (25), 14610-7, 2003.
  20. Russell, CJ, Kantor, KL, Jardetzky, TS, Lamb, RA. A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion. J Cell Biol, 163 (2), 363-74, 2003.
  21. Russell, CJ, Jardetzky, TS, Lamb, RA. Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO J, 20 (15), 4024-34, 2001.
  22. Paterson, RG, Russell, CJ, Lamb, RA. Fusion protein of the paramyxovirus SV5: destabilizing and stabilizing mutants of fusion activation. Virology, 270 (1), 17-30, 2000.
  23. Epand, RF, Macosko, JC, Russell, CJ, Shin, YK, Epand, RM. The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. J Mol Biol, 286 (2), 489-503, 1999.
  24. Russell, CJ, Thorgeirsson, TE, Shin, YK. The membrane affinities of the aliphatic amino acid side chains in an alpha-helical context are independent of membrane immersion depth. Biochemistry, 38 (1), 337-46, 1999.
  25. Russell, CJ, King, DS, Thorgeirsson, TE, Shin, YK. De novo design of a peptide which partitions between water and phospholipid bilayers as a monomeric alpha-helix. Protein Eng, 11 (7), 539-47, 1998.
  26. Russell, CJ, Thorgeirsson, TE, Shin, YK. Temperature dependence of polypeptide partitioning between water and phospholipid bilayers. Biochemistry, 35 (29), 9526-32, 1996.
  27. Thorgeirsson, TE, Russell, CJ, King, DS, Shin, YK. Direct determination of the membrane affinities of individual amino acids. Biochemistry, 35 (6), 1803-9, 1996.