MULLIGHAN, CHARLES G.

Professor
Pathology

Office: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
262 DANNY THOMAS PLACE
MEMPHIS TN 381120342
Tel: (901) 595-3387
cmulligh@uthsc.edu

Publications

  1. DeBoer, R, Koval, G, Mulkey, F, Wetzler, M, Devine, S, Marcucci, G, Stone, RM, Larson, RA, Bloomfield, CD, Geyer, S, Mullighan, CG, Stock, W. Clinical impact of ABL1 kinase domain mutations and IKZF1 deletion in adults under age 60 with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL): molecular analysis of CALGB (Alliance) 10001 and 9665. Leuk Lymphoma, 57 (10), 2298-306, 2016.
  2. Yang, W, Wu, G, Broeckel, U, Smith, CA, Turner, V, Haidar, CE, Wang, S, Carter, R, Karol, SE, Neale, G, Crews, KR, Yang, JJ, Mullighan, CG, Downing, JR, Evans, WE, Relling, MV. Comparison of genome sequencing and clinical genotyping for pharmacogenes. Clin Pharmacol Ther, 100 (4), 380-8, 2016.
  3. Zaliova, M, Moorman, AV, Cazzaniga, G, Stanulla, M, Harvey, RC, Roberts, KG, Heatley, SL, Loh, ML, Konopleva, M, Chen, IM, Zimmermannova, O, Schwab, C, Smith, O, Mozziconacci, MJ, Chabannon, C, Kim, M, Frederik Falkenburg, JH, Norton, A, Marshall, K, Haas, OA, Starkova, J, Stuchly, J, Hunger, SP, White, D, Mullighan, CG, Willman, CL, Stary, J, Trka, J, Zuna, J. Characterization of leukemias with ETV6-ABL1 fusion. Haematologica, 101 (9), 1082-93, 2016.
  4. Matlawska-Wasowska, K, Kang, H, Devidas, M, Wen, J, Harvey, RC, Nickl, CK, Ness, SA, Rusch, M, Li, Y, Onozawa, M, Martinez, C, Wood, BL, Asselin, BL, Chen, IM, Roberts, KG, Baruchel, A, Soulier, J, Dombret, H, Zhang, J, Larson, RS, Raetz, EA, Carroll, WL, Winick, NJ, Aplan, PD, Loh, ML, Mullighan, CG, Hunger, SP, Heerema, NA, Carroll, AJ, Dunsmore, KP, Winter, SS. MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study. Leukemia, 30 (9), 1909-12, 2016.
  5. Herold, T, Schneider, S, Metzeler, K, Neumann, M, Hartmann, L, Roberts, KG, Konstandin, NP, Greif, PA, Bräundl, K, Ksienzyk, B, Huk, N, Schneider, I, Zellmeier, E, Jurinovic, V, Mansmann, U, Hiddemann, W, Mullighan, CG, Bohlander, SK, Spiekermann, K, Hölzer, D, Brüggemann, M, Baldus, CD, Dreyling, M, Gökbuget, N. Philadelphia chromosome-like acute lymphoblastic leukemia in adults have frequent IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis. Haematologica, 2016.
  6. Pang, SH, Minnich, M, Gangatirkar, P, Zheng, Z, Ebert, A, Song, G, Dickins, RA, Corcoran, LM, Mullighan, CG, Busslinger, M, Huntington, ND, Nutt, SL, Carotta, S. PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia. Leukemia, 30 (6), 1375-87, 2016.
  7. Chiaretti, S, Gianfelici, V, O'Brien, SM, Mullighan, CG. Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia. Am Soc Clin Oncol Educ Book, 35, e314-22, 2016.
  8. Weiss, MJ, Mullighan, CG. Welcoming a new age for gene therapy in hematology. Blood, 127 (21), 2523-4, 2016.
  9. Churchman, ML, Evans, K, Richmond, J, Robbins, A, Jones, L, Shapiro, IM, Pachter, JA, Weaver, DT, Houghton, PJ, Smith, MA, Lock, RB, Mullighan, CG. Synergism of FAK and tyrosine kinase inhibition in Ph(+) B-ALL. JCI Insight, 1 (4), 2016.
  10. Iacobucci, I, Li, Y, Roberts, KG, Dobson, SM, Kim, JC, Payne-Turner, D, Harvey, RC, Valentine, M, McCastlain, K, Easton, J, Yergeau, D, Janke, LJ, Shao, Y, Chen, IM, Rusch, M, Zandi, S, Kornblau, SM, Konopleva, M, Jabbour, E, Paietta, EM, Rowe, JM, Pui, CH, Gastier-Foster, J, Gu, Z, Reshmi, S, Loh, ML, Racevskis, J, Tallman, MS, Wiernik, PH, Litzow, MR, Willman, CL, McPherson, JD, Downing, JR, Zhang, J, Dick, JE, Hunger, SP, Mullighan, CG. Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. Cancer Cell, 29 (2), 186-200, 2016.
  11. Moriyama, T, Metzger, ML, Wu, G, Nishii, R, Qian, M, Devidas, M, Yang, W, Cheng, C, Cao, X, Quinn, E, Raimondi, S, Gastier-Foster, JM, Raetz, E, Larsen, E, Martin, PL, Bowman, WP, Winick, N, Komada, Y, Wang, S, Edmonson, M, Xu, H, Mardis, E, Fulton, R, Pui, CH, Mullighan, C, Evans, WE, Zhang, J, Hunger, SP, Relling, MV, Nichols, KE, Loh, ML, Yang, JJ. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol, 16 (16), 1659-66, 2015.
  12. Mullighan, CG, Jeha, S, Pei, D, Payne-Turner, D, Coustan-Smith, E, Roberts, KG, Waanders, E, Choi, JK, Ma, X, Raimondi, SC, Fan, Y, Yang, W, Song, G, Yang, JJ, Inaba, H, Downing, JR, Leung, WH, Bowman, WP, Relling, MV, Evans, WE, Zhang, J, Campana, D, Pui, CH. Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels. Blood, 126 (26), 2896-9, 2015.
  13. Kucine, N, Marubayashi, S, Bhagwat, N, Papalexi, E, Koppikar, P, Sanchez Martin, M, Dong, L, Tallman, MS, Paietta, E, Wang, K, He, J, Lipson, D, Stephens, P, Miller, V, Rowe, JM, Teruya-Feldstein, J, Mullighan, CG, Ferrando, AA, Krivtsov, A, Armstrong, S, Leung, L, Ochiana, SO, Chiosis, G, Levine, RL, Kleppe, M. Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood, 126 (22), 2479-83, 2015.
  14. Hunger, SP, Mullighan, CG. Acute Lymphoblastic Leukemia in Children. N Engl J Med, 373 (16), 1541-52, 2015.
  15. Pui, CH, Yang, JJ, Hunger, SP, Pieters, R, Schrappe, M, Biondi, A, Vora, A, Baruchel, A, Silverman, LB, Schmiegelow, K, Escherich, G, Horibe, K, Benoit, YC, Izraeli, S, Yeoh, AE, Liang, DC, Downing, JR, Evans, WE, Relling, MV, Mullighan, CG. Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. J Clin Oncol, 33 (27), 2938-48, 2015.
  16. Perlman, EJ, Gadd, S, Arold, ST, Radhakrishnan, A, Gerhard, DS, Jennings, L, Huff, V, Guidry Auvil, JM, Davidsen, TM, Dome, JS, Meerzaman, D, Hsu, CH, Nguyen, C, Anderson, J, Ma, Y, Mungall, AJ, Moore, RA, Marra, MA, Mullighan, CG, Ma, J, Wheeler, DA, Hampton, OA, Gastier-Foster, JM, Ross, N, Smith, MA. MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours. Nat Commun, 6, 10013, 2015.
  17. Gooskens, SL, Gadd, S, Guidry Auvil, JM, Gerhard, DS, Khan, J, Patidar, R, Meerzaman, D, Chen, QR, Hsu, CH, Yan, C, Nguyen, C, Hu, Y, Mullighan, CG, Ma, J, Jennings, LJ, de Krijger, RR, van den Heuvel-Eibrink, MM, Smith, MA, Ross, N, Gastier-Foster, JM, Perlman, EJ. TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. Oncotarget, 6 (18), 15828-41, 2015.
  18. Xu, H, Zhang, H, Yang, W, Yadav, R, Morrison, AC, Qian, M, Devidas, M, Liu, Y, Perez-Andreu, V, Zhao, X, Gastier-Foster, JM, Lupo, PJ, Neale, G, Raetz, E, Larsen, E, Bowman, WP, Carroll, WL, Winick, N, Williams, R, Hansen, T, Holm, JC, Mardis, E, Fulton, R, Pui, CH, Zhang, J, Mullighan, CG, Evans, WE, Hunger, SP, Gupta, R, Schmiegelow, K, Loh, ML, Relling, MV, Yang, JJ. Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children. Nat Commun, 6, 7553, 2015.