CHARLES W. LEFFLER, Ph.D., M.S., B.S.

Professor Emeritus
Physiology

Office: G210 COLEMAN BUILDING
956 COURT AVENUE
MEMPHIS TN 381632116
Tel: (901) 448-7122
cleffler@uthsc.edu

Education

  • PostDoc, University of Florida, Gainesville, FL, Physiology
  • M.S., University of Florida, Gainesville, FL, Comparative Physiology
  • Ph.D., University of Florida, Gainesville, FL, Comparative Physiology
  • B.S., University of Miami, Coral Gables, FL, Biology
  • B.S., University of Miami, Coral Gables, FL, Biology
  • DePauw University, Greencastle, IN, Biology
  • DePauw University, Greencastle, IN, Biology

Research description

The primary focus of this research involves autocrine/paracrine control of the newborn cerebral microvasculature during physiologically stressful and pathological situations, and the cellular mechanisms involved in such control. We investigate autocrine and paracrine communication within the vessel wall, with specific current focus on the novel gasotransmitter, carbon monoxide.

Research interest/specialty

CO in microvascular control of neonatal cerebral circulation.

Research interest/specialty

CO in microvascular control of neonatal cerebral circulation.

Research description

The primary focus of this research involves autocrine/paracrine control of the newborn cerebral microvasculature during physiologically stressful and pathological situations, and the cellular mechanisms involved in such control. We investigate autocrine and paracrine communication within the vessel wall, with specific current focus on the novel gasotransmitter, carbon monoxide.

Publications

  1. Narayanan, N, Leffler, CW, Daley, ML. Influence of Hypercapnic Vasodilation on Cerebrovascular Autoregulation and Pial Arteriolar Bed Resistance in Piglets. J Appl Physiol, 2008.
  2. Parfenova, H, Leffler, CW. Cerebroprotective functions of HO-2. Curr Pharm Des, 14 (5), 443-53, 2008.
  3. Li, A, Xi, Q, Umstot, ES, Bellner, L, Schwartzman, ML, Jaggar, JH, Leffler, CW. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels. Circ Res, 102 (2), 234-41, 2008.
  4. Kanu, A, Leffler, CW. Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs. Am J Physiol Heart Circ Physiol, 293 (5), H3193-200, 2007.