MEMPHIS TN 381632116
Tel: (901) 448-5813


  • AGAF, American Gastroenterological Association, Gastroenterology
  • FACP, American College of Physicians, Medicine
  • FCP, American College of Clinical Pharmacology, Clinical Pharmacology
  • FACG, American College of Gastroenterology, Gastroenterology
  • FRCP (Glasg.), Royal College of Physicians and Surgeons of Glasgow, Medicine
  • MRCP (UK), Royal Colleges of Physicians, Medicine
  • MB ChB, University of Glasgow, Medicine

My Current CV

Research Keywords

Proton pump inhibitors, acid reflux, H. pylori, dyspepsia, functional dyspepsia, meta-analysis, systematic review

Research Interest/Specialty

Clinical gastroenterology Acid peptic disorders Peptic ulcer disease Gastroesophageal reflux disease (GERD) Helicobacter pylori (H. pylori) infection Dyspepsia and functional dyspepsia Clinical pharmacology of gastrointestinal disorders Functional gastrointestinal disorders Nonsteroidal anti-inflammatory drugs Upper gastrointestinal bleeding Acid-suppressing drugs


  1. Khan, MA, Ali, B, Lee, WM, Howden, CW. Mesalamine Does Not Help Prevent Recurrent Acute Colonic Diverticulitis: Meta-Analysis of Randomized, Placebo-Controlled Trials. Am J Gastroenterol, 111 (4), 579-81, 2016.
  2. Khan, MA, Kamal, S, Khan, S, Lee, WM, Howden, CW. Systematic review and meta-analysis of the possible association between pharmacological gastric acid suppression and spontaneous bacterial peritonitis. Eur J Gastroenterol Hepatol, 27 (11), 1327-36, 2015.
  3. Khan, MA, Howden, CW. Letter: possible association between PPI use and spontaneous bacterial peritonitis. Aliment Pharmacol Ther, 42 (6), 778-9, 2015.
  4. Talley, NJ, Locke, GR, Saito, YA, Almazar, AE, Bouras, EP, Howden, CW, Lacy, BE, DiBaise, JK, Prather, CM, Abraham, BP, El-Serag, HB, Moayyedi, P, Herrick, LM, Szarka, LA, Camilleri, M, Hamilton, FA, Schleck, CD, Tilkes, KE, Zinsmeister, AR. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology, 149 (2), 340-9.e2, 2015.
  5. Patel, KA, Howden, CW. Update on the Diagnosis and Management of Helicobacter pylori Infection in Adults. J Clin Gastroenterol, 49 (6), 461-7, 2015.
  6. Howden, CW. PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin. Aliment Pharmacol Ther, 40 (11-12), 1367, 2014.
  7. Kahrilas, PJ, Persson, T, Denison, H, Wernersson, B, Hughes, N, Howden, CW. Editorial: healing of refractory reflux oesophagitis--an ongoing unmet clinical need; authors' reply. Aliment Pharmacol Ther, 40 (8), 989, 2014.
  8. Kahrilas, PJ, Persson, T, Denison, H, Wernersson, B, Hughes, N, Howden, CW. Predictors of either rapid healing or refractory reflux oesophagitis during treatment with potent acid suppression. Aliment Pharmacol Ther, 40 (6), 648-56, 2014.
  9. Gawron, AJ, French, DD, Pandolfino, JE, Howden, CW. Economic evaluations of gastroesophageal reflux disease medical management. Pharmacoeconomics, 32 (8), 745-58, 2014.
  10. Howden, CW, Chey, WD, Vakil, NB. Clinical Rationale for Confirmation Testing After Treatment of Helicobacter pylori Infection: Implications of Rising Antibiotic Resistance. Gastroenterol Hepatol (N Y), 10 (7 Suppl 3), 1-19, 2014.
  11. Kahrilas, PJ, Jonsson, A, Denison, H, Wernersson, B, Hughes, N, Howden, CW. Impact of regurgitation on health-related quality of life in gastro-oesophageal reflux disease before and after short-term potent acid suppression therapy. Gut, 63 (5), 720-6, 2014.
  12. Leontiadis, GI, Molloy-Bland, M, Moayyedi, P, Howden, CW. Response to Nahon et al. and Marmo et al. Am J Gastroenterol, 108 (9), 1534-5, 2013.
  13. Neumann, I, Letelier, LM, Rada, G, Claro, JC, Martin, J, Howden, CW, Yuan, Y, Leontiadis, GI. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev (6), CD007999, 2013.
  14. Howden, CW. Commentary: improving the use of gastroprotective agents among high-risk NSAID users. Aliment Pharmacol Ther, 37 (10), 1019, 2013.
  15. Kahrilas, PJ, Howden, CW, Wernersson, B, Denison, H, Nuevo, J, Gisbert, JP. Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study. Aliment Pharmacol Ther, 37 (10), 1005-10, 2013.
  16. Leontiadis, GI, Molloy-Bland, M, Moayyedi, P, Howden, CW. Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. Am J Gastroenterol, 108 (3), 331-45; quiz 346, 2013.
  17. Kahrilas, PJ, Howden, CW, Hughes, N, Molloy-Bland, M. Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease. Chest, 143 (3), 605-12, 2013.
  18. Lynch, KL, Pandolfino, JE, Howden, CW, Kahrilas, PJ. Major complications of pneumatic dilation and Heller myotomy for achalasia: single-center experience and systematic review of the literature. Am J Gastroenterol, 107 (12), 1817-25, 2012.
  19. Howden, CW. Commentary: PPIs and risk of serious infection in decompensated cirrhosis. Aliment Pharmacol Ther, 36 (11-12), 1094; discussion 1095, 2012.
  20. Howden, CW. Commentary: The link between community-acquired pneumonia and PPI use. Aliment Pharmacol Ther, 36 (11-12), 1101, 2012.
  21. Leontiadis, GI, Howden, CW, Barkun, AN. High-dose versus low-dose intravenous proton pump inhibitor treatment for bleeding peptic ulcers. Expert Rev Gastroenterol Hepatol, 6 (6), 675-7, 2012.
  22. Elfant, AB, Howden, CW, Stollman, N. Contemporary Diagnostic Strategies for the Detection of Helicobacter pylori Infection. Gastroenterol Hepatol (N Y), 8 (11 Suppl 7), 1-16, 2012.
  23. Kahrilas, PJ, Jonsson, A, Denison, H, Wernersson, B, Hughes, N, Howden, CW. Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression. Am J Gastroenterol, 107 (9), 1354-60, 2012.
  24. Metz, DC, Choi, J, Strosberg, J, Heaney, AP, Howden, CW, Klimstra, D, Yao, JC. A rationale for multidisciplinary care in treating neuroendocrine tumours. Curr Opin Endocrinol Diabetes Obes, 19 (4), 306-13, 2012.
  25. Leontiadis, GI, Miller, MA, Howden, CW. How much do PPIs contribute to C. difficile infections. Am J Gastroenterol, 107 (7), 1020-1, 2012.
  26. Kahrilas, PJ, Jonsson, A, Denison, H, Wernersson, B, Hughes, N, Howden, CW. Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol, 10 (6), 612-9, 2012.
  27. Talley, NJ, Locke, GR, Herrick, LM, Silvernail, VM, Prather, CM, Lacy, BE, DiBaise, JK, Howden, CW, Brenner, DM, Bouras, EP, El-Serag, HB, Abraham, BP, Moayyedi, P, Zinsmeister, AR. Functional Dyspepsia Treatment Trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemp Clin Trials, 33 (3), 523-33, 2012.
  28. Chen, J, Yuan, YC, Leontiadis, GI, Howden, CW. Recent safety concerns with proton pump inhibitors. J Clin Gastroenterol, 46 (2), 93-114, 2012.