BURT M. SHARP, M.D., B.A.

Professor
Genetics,Genomics&Informatics

Office: 220 CANCER RESEARCH BUILDING
19 SOUTH MANASSAS
MEMPHIS TN 381033403
Tel: (901) 448-6001
bsharp@uthsc.edu

Education

  • M.D., University of Cincinnati College of Medicine, Medicine
  • B.A., State University of New York Stony Brook, n/a

Research interest/specialty

Nicotine and opioid receptor pathways in brain stress-responsive systems.

Research interest/specialty

Nicotine and opioid receptor pathways in brain stress-responsive systems.

Publications

  1. Wang, F, Chen, H, Sharp, BM. Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats. J Neurochem, 2008.
  2. Chen, H, Fu, Y, Sharp, BM. Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress. Neuropsychopharmacology, 33 (4), 721-30, 2008.
  3. Yu, G, Chen, H, Zhao, W, Matta, SG, Sharp, BM. Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation. J Neurosci, 28 (11), 2773-82, 2008.
  4. Shahabi, NA, McAllen, K, Sharp, BM. Stromal cell-derived factor 1-alpha (SDF)-induced human T cell chemotaxis becomes phosphoinositide 3-kinase (PI3K)-independent: role of PKC-theta. J Leukoc Biol, 83 (3), 663-71, 2008.
  5. Chen, H, Matta, SG, Sharp, BM. Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug. Neuropsychopharmacology, 32 (3), 700-9, 2007.
  6. Zhao, R, Chen, H, Sharp, BM. Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius. J Pharmacol Exp Ther, 320 (2), 837-44, 2007.
  7. Wang, F, Chen, H, Steketee, JD, Sharp, BM. Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration. Neuropsychopharmacology, 32 (1), 103-9, 2007.
  8. Sharp, BM. Multiple opioid receptors on immune cells modulate intracellular signaling. Brain Behav Immun, 20 (1), 9-14, 2006.
  9. Chen, H, Parker, SL, Matta, SG, Sharp, BM. Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats. Eur J Neurosci, 22 (2), 380-8, 2005.
  10. Chen, H, Sharp, BM. Content-rich biological network constructed by mining PubMed abstracts. BMC Bioinformatics, 5, 147, 2004.
  11. Sharp, BM, Yatsula, M, Fu, Y. Effects of galantamine, a nicotinic allosteric potentiating ligand, on nicotine-induced catecholamine release in hippocampus and nucleus accumbens of rats. J Pharmacol Exp Ther, 309 (3), 1116-23, 2004.
  12. Parker, SL, Fu, Y, McAllen, K, Luo, J, McIntosh, JM, Lindstrom, JM, Sharp, BM. Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit. Mol Pharmacol, 65 (3), 611-22, 2004.
  13. Sharp, BM. Opioid receptor expression and function. J Neuroimmunol, 147 (1-2), 3-5, 2004.
  14. Kane, VB, Fu, Y, Matta, SG, Sharp, BM. Gestational nicotine exposure attenuates nicotine-stimulated dopamine release in the nucleus accumbens shell of adolescent Lewis rats. J Pharmacol Exp Ther, 308 (2), 521-8, 2004.
  15. Fu, Y, Matta, SG, Kane, VB, Sharp, BM. Norepinephrine release in amygdala of rats during chronic nicotine self-administration: an in vivo microdialysis study. Neuropharmacology, 45 (4), 514-23, 2003.
  16. Sharp, BM. Opioid receptor expression and intracellular signaling by cells involved in host defense and immunity. Adv Exp Med Biol, 521, 98-105, 2003.
  17. Shahabi, NA, McAllen, K, Sharp, BM. Phosphorylation of activating transcription factor in murine splenocytes through delta opioid receptors. Cell Immunol, 221 (2), 122-7, 2003.
  18. Chen, H, Sharp, BM. Oliz, a suite of Perl scripts that assist in the design of microarrays using 50mer oligonucleotides from the 3' untranslated region. BMC Bioinformatics, 3, 27, 2002.
  19. Brower, VG, Fu, Y, Matta, SG, Sharp, BM. Rat strain differences in nicotine self-administration using an unlimited access paradigm. Brain Res, 930 (1-2), 12-20, 2002.
  20. Sharp, BM. Lymphocyte modulation by seven transmembrane receptors: a brief review of session 1. Adv Exp Med Biol, 493, 255-8, 2001.
  21. Fu, Y, Matta, SG, Brower, VG, Sharp, BM. Norepinephrine secretion in the hypothalamic paraventricular nucleus of rats during unlimited access to self-administered nicotine: An in vivo microdialysis study. J Neurosci, 21 (22), 8979-89, 2001.
  22. Sharp, BM, McAllen, K, Gekker, G, Shahabi, NA, Peterson, PK. Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression. J Immunol, 167 (2), 1097-102, 2001.
  23. Sharp, BM, Li, MD, Matta, SG, McAllen, K, Shahabi, NA. Expression of delta opioid receptors and transcripts by splenic T cells. Ann N Y Acad Sci, 917, 764-70, 2001.
  24. Fu, Y, Matta, SG, Gao, W, Sharp, BM. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience, 101 (2), 369-75, 2000.
  25. Shahabi, NA, McAllen, K, Matta, SG, Sharp, BM. Expression of delta opioid receptors by splenocytes from SEB-treated mice and effects on phosphorylation of MAP kinase. Cell Immunol, 205 (2), 84-93, 2000.
  26. Kane, JK, Parker, SL, Matta, SG, Fu, Y, Sharp, BM, Li, MD. Nicotine up-regulates expression of orexin and its receptors in rat brain. Endocrinology, 141 (10), 3623-9, 2000.
  27. Fu, Y, Matta, SG, Gao, W, Brower, VG, Sharp, BM. Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area. J Pharmacol Exp Ther, 294 (2), 458-65, 2000.
  28. Li, MD, Kane, JK, Parker, SL, McAllen, K, Matta, SG, Sharp, BM. Nicotine administration enhances NPY expression in the rat hypothalamus. Brain Res, 867 (1-2), 157-64, 2000.
  29. Li, MD, Kane, JK, Matta, SG, Blaner, WS, Sharp, BM. Nicotine enhances the biosynthesis and secretion of transthyretin from the choroid plexus in rats: implications for beta-amyloid formation. J Neurosci, 20 (4), 1318-23, 2000.
  30. Fu, Y, Matta, SG, McIntosh, JM, Sharp, BM. Inhibition of nicotine-induced hippocampal norepinephrine release in rats by alpha-conotoxins MII and AuIB microinjected into the locus coeruleus. Neurosci Lett, 266 (2), 113-6, 1999.
  31. Li, MD, McAllen, K, Sharp, BM. Regulation of delta opioid receptor expression by anti-CD3-epsilon, PMA, and ionomycin in murine splenocytes and T cells. J Leukoc Biol, 65 (5), 707-14, 1999.
  32. Fu, Y, Matta, SG, Sharp, BM. Local alpha-bungarotoxin-sensitive nicotinic receptors modulate hippocampal norepinephrine release by systemic nicotine. J Pharmacol Exp Ther, 289 (1), 133-9, 1999.