MOORE, BOB M.

Professor
Pharmaceutical Sciences

Office: 327d Johnson Building
Tel: (901) 448-6085
bmoore@uthsc.edu

Education

  • PostDoc, University of Texas, Structural Biology
  • Ph.D., University of Kansas, Medicinal Chemistry
  • M.S., Indiana State University, Chemistry
  • B.S., Indiana State University, Chemistry/Physics

Research Interest/Specialty

The design, synthesis, and evaluation of cannabinoid based therapeutic agents

Research Keywords

Cannabinoid, Inflammation, Cancer, Drug Development

Publications

  1. Brocato, B, Zoerner, AA, Janjetovic, Z, Skobowiat, C, Gupta, S, Moore, BM, Slominski, A, Zhang, J, Schenone, M, Phinehas, R, Ferry, RJ, Dick, E, Hubbard, GB, Mari, G, Schlabritz-Loutsevitch, N. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta, 34 (11), 983-9, 2013.
  2. B. M. Moore II, S. Gurley, S. Mustafa, and P. Allison. Pyrimidine non-classical cannabinoid compounds and related methods of use. U.S. Patent 8,541,431, 2013.
  3. B. M. Moore II, S. Gurley, and S. Mustafa. Pyridine non-classical cannabinoid compounds and related methods of use. U.S. Patent 8,349,876, 2013.
  4. B. M. Moore II, S. Gurley, S. Mustafa, and P. Allison. Pyrimidine Non-Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,389,534, 2013.
  5. B. M. Moore II, S. Gurley, and S. Mustafa. Benzofuran Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,476,309, 2013.
  6. B. M. Moore II, S. Gurley, and S. Mustafa. Furanopyridine Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,431,595, 2013.
  7. B. M. Moore II, S. Gurley, and S. Mustafa. Pyridine Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,476,439, 2013.
  8. Gurley, SN, Abidi, AH, Allison, P, Guan, P, Duntsch, C, Robertson, JH, Kosanke, SD, Keir, ST, Bigner, DD, Elberger, AJ, Moore, BM. Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233. J Neurooncol, 110 (2), 163-77, 2012.
  9. B. M. Moore II, S. Gurley, and S. Mustafa. Pyridine Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,124,771, 2012.
  10. B. M. Moore II, S. Gurley, S. Mustafa, and P. Allison. Pyrimidine Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,324,228, 2012.
  11. B. M. Moore II, S. Gurley, and S. Mustafa. Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,158,654, 2012.
  12. Bhattacharjee, H, Nadipuram, A, Kosanke, S, Kiani, MF, Moore, BM. Low-volume binary drug therapy for the treatment of hypovolemia. Shock, 35 (6), 590-6, 2011.
  13. Vaddady, PK, Mehrotra, N, Zhang, X, Yates, CR, Moore, BM, Meibohm, B. Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock. Biopharm Drug Dispos, 32 (2), 89-98, 2011.
  14. B. M. Moore II, H. Bhattachjare, C. Y. Yates, L. Stuart. Tri-aryl Cannabinoids and Use Thereof. U.S. Patent 7,888,365, 2011.
  15. B. M. Moore II, S. Gurley, S. Mustafa, and P. Allison. Pyrimidine Classical Cannabinoid Compounds and Related Methods of Use. U.S. Patent 8,022,078, 2011.
  16. Bhattacharjee, H, Gurley, SN, Allison, PB, Zhang, X, Moore, BM. Evaluation of novel vanilloid-based hemostatic agents in rats. J Trauma, 68 (3), 676-81, 2010.
  17. Bhattacharjee, H, Gurley, SN, Moore, BM. Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. Bioorg Med Chem Lett, 19 (6), 1691-3, 2009.
  18. Ferreira, AM, Krishnamurthy, M, Moore, BM, Finkelstein, D, Bashford, D. Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations. Bioorg Med Chem, 17 (6), 2598-606, 2009.
  19. Krishnamurthy, M, Gurley, S, Moore, BM. Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem, 16 (13), 6489-500, 2008.
  20. D. D. Miller. B. M. Moore II,.S. Mustafa, D. R. Feller, S. A. Bavadekar.. Yohimbine Derivatives and Use Thereof. U.S. Patent 7,470,703, 2008.
  21. B.M. Moore II, A. Ferreira, M. Krishnamurthy. Cannabinoid Derivatives, Methods of Making, and Use Thereof. U.S. Patent 7,169,942, 2007.
  22. R. Nallamothu, G. C. Wood, M. F. Kiani, B. M. Moore, F. P. Horton, L. A. Thoma. A targeted liposome delivery system for combretastatin A4: Formulation optimization through drug loading and in vitro release studies. PDA Journal of Pharmaceutical Science & Technology, 60, 1-12, 2006.
  23. S.A. Bavadekar, G. Ma, S. M. Mustafa, B. M. Moore, D. D. Miller, D. R. Feller. Tethered Yohimbine Analogs as Selective Human 2C-Adrenergic Receptor Ligands. J. Pharmacol. Exp. Ther., 319, 739-48, 2006.
  24. B.M. Moore II. Method for Regulation of Microvascular Tone. U.S. Patent 6,916,852, 2005.
  25. C. Duntsch, M. K. Divi, T. Jones, Q. Zhou, M. Krishnamurthy, G. Wood, A. Sills, and B. M. Moore II. Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma. J. Neurooncol, 29, 1-10, 2005.
  26. S. M. Mustafa, S. A. Bavadekar, G. M, B. M. Moore, D. R. Feller, and D. D. Miller. Synthesis and Biological Studies of Yohimbine Derivatives on Human 2C-Adrenergic Receptors. Bioorg. Med. Chem. Lett., 15, 2758-2760, 2005.
  27. S. M. Kerwin, L. H. Hurley, M. R. DeLuca, B. M. Moore II, G. S. Mundy.. Methods and Compositions for Stimulating Osteoblast Proliferation or Treating Malignant Cell Proliferation and Methods for Selecting Osteoblast Proliferation Stimulants. U.S. Patent 6,720,344, 2004.
  28. M. B. Doughty, K. Aboudehen, G. Anderson, K. Li, B. Moore II, and T. Poolson. Side-Chain Conformational Restriction in Template-Competitive Inhibitors of E. coli DNA Polymerase I Klenow Fragment: Synthesis, Structural Characterization and Inhibition Activity. Nucleosides, Nucleotides, and Nucleic Acids, 23, 1751-1765, 2004.
  29. A. Ferreira, B. M. Moore II, M. Krishmurthy. Theoretical Analysis of the NMR and Electronic Structure of Novel 8-THC Derivatives. J. Theochem., 674, 131, 2004.
  30. S. G. Lalchandani, X. Zhang, S. S. Hong, S. B. Liggett, W. Li, B. M. Moore II, D. D. Miller, and D. R. Feller. Medetomidine Analogs as Selective Agonist for the Human 2- Adrenoceptors. Biochem. Pharmacol., 67, 87, 2004.
  31. M. Krishmurthy, A. Ferreira, B. M. Moore II. Synthesis and Testing of Novel Phenyl Substituted Side Chain Analogs of Classical Cannabinoids. Bioorg. Med. Chem. Lett., 13, 3487, 2003.
  32. W. Lin, K. Li, B. Moore II, and M. B. Doughty. Conformational Properties of Template Competitive HIV-1 Reverse Transcriptase Inhibitors: Analysis of Enzyme Binding Modes. Nucleosides, Nucleotides, and Nucleic Acids, 22, 283, 2003.
  33. A. Nadipuram, M. Krishmurthy, A. Ferreira, W. Li, and B. M. Moore II. Synthesis and Testing of Novel Classical Cannabinoids: Exploring the Side Chain Ligand Binding Pocket of the CB1 and CB2 Receptors. Bioorg. Med. Chem., 11, 3121, 2003.
  34. D. D. Miller, W. Zheng, S. Mustafa, B. M. Moore II. Yohimbine Dimers Exhibiting Binding Selectivities for α2 Adrenergic Receptors. U.S. Patent 6,638,943, 2003.
  35. M. Krishmurthy, W. Li, B. M. Moore II. Synthesis, Biological Evaluation, and Structural Studies on N1 and C5 Substituted Cycloalkyl Analogs of the Pyrazole Class of CB1 and CB2 Ligands. Bioorg. Med. Chem., 12, 393, 2003.
  36. . K. Li, W. Lin, K. H. Chong, B. M. Moore, M. B. Doughty. Template-Competitive Inhibitors of HIV-1 Reverse Transcriptase: Design, Synthesis and Inhibitory Activity. Bioorg. Med. Chem., 10, 507, 2002.
  37. S. G. Lalchandani, L. Lei, W. Zheng, M. M. Suni, B. M. Moore, S.B. Liggett, D. D. Miller, D. R. Feller. Yohimbine Dimers Exhibiting Selectivity for the Human α2c-Adrenoceptor Subtype. J. Pharmacol. Exp. Ther., 303, 879, 2002.
  38. C. A. Marhefka, B. M. Moore II, T.C. Bishop, L. Kirkovsky, A. Mukherjee, J. T. Dalton, D. D. Miller. Homology Modeling Using Multiple Molecular Dynamics Simulations and Docking Studies of the Human Androgen Receptor Ligand Binding Domain Bound to Testosterone and Nonsteroidal Ligands. J. Med. Chem., 44, 1729, 2001.
  39. B. M. Moore, F. Seaman, L. H. Hurley. Molecular Recognition of DNA by Ecteinascidin 743. Recent Trends in Molecular Recognition, 26, 1998.
  40. B. M. Moore II, F. C. Seaman, R. T. Wheelhouse, L. H. Hurley. Mechanism for the Catalytic Activation of Ecteinascidin 743 and Its Subsequent Alkylation of Guanine N2. J. Am. Chem. Soc., 120, 2490, 1998.
  41. B. M. Moore II, F. C. Seaman, L. H. Hurley. NMR-Based Model of an Ecteinascidin 743-DNA Adduct. J. Am. Chem. Soc., 119, 5475, 1997.
  42. B. M. Moore, R. Jalluri, M. B. Doughty. DNA Polymerase Photoprobe 2-[(4-Azidophenacyl)thio]-2’-Deoxyadenosine 5’-Triphosphate Labels an Eschericia coli DNA Polymerase I Klenow Fragment Substrate Binding Site. Biochemistry, 36, 11642, 1995.
  43. B. M. Moore, K. Li, M. B. Doughty. Deoxyadenosine-Based DNA Polymerase Photoprobes: Design, Synthesis, and Characterization as Inhibitors of the Eschericia coli DNA Polymerase I Klenow Fragment. Biochemistry, 35, 11634, 1995.
  44. D. Flaherty, P. Balse, K. Li, B. M. Moore, M. B. Doughty. Synthesis of 2-Azido-1,N6-Etheno and 2-Azido Analogs of Deoxyadenosine as Nucleotide Photoaffinity Labels. Nucleosides and Nucleotides, 14, 65, 1994.
  45. B. M. Moore, W. H. Flurkey. Sodium Dodecyl Sulfate Activation of a Plant Polyphenoloxidase. J. Biol. Chem., 265, 4982, 1990.