JONES, BYRON C.

Professor
Genetics,Genomics&Informatics
 
Professor
Pharmacology

Office: 410J TRANSLATIONAL RESEARCH BUILDING
71 SOUTH MANASSAS
MEMPHIS TN 38163
Tel: (901) 448-2814
bjone129@uthsc.edu

Education

  • PostDoc, The University of Colorado, Boulder, Pharmacogenetics
  • PostDoc, The University of Arizona, Neuropharmacology
  • Ph.D., The University of Arizona, Physiological Psychology

Research Description

My research interests are focused on individual differences in the following:

Response to chronic and acute stress in adaptation and alcohol consumption

Susceptibility to toxicity of pesticides and heavy metals

Regulation of copper, iron and zinc in the brain

The methods of study include genetic reference populations of mice and we perform both genetic and genomic anaiyses

Research Keywords

brain, iron, copper, zinc, alcohol, cocaine, cannabinoids, dopamine, chronic and acute stress

Research Interest/Specialty

Neuropharmacology of alcohol and drugs of abuse

Pharmacogenetics of CNS drugs

Toxicogenetics of pesticides and heavy metals

Genetics of iron, copper and zinc regulation in the brain

Chronic stress effects on alcohol and drug use

Genetic architecture of the hypothalamo-pituitary-adrenal axis

Publications

  1. Urquhart, KR, Zhao, Y, Baker, JA, Lu, Y, Yan, L, Cook, MN, Jones, BC, Hamre, KM, Lu, L. A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors. Neurogenetics, 2016.
  2. Alam, G, Jones, BC. Toxicogenetics: in search of host susceptibility to environmental toxicants. Front Genet, 5, 327, 2014.
  3. Unger, EL, Bianco, LE, Jones, BC, Allen, RP, Earley, CJ. Low brain iron effects and reversibility on striatal dopamine dynamics. Exp Neurol, 261, 462-8, 2014.
  4. Tarantino, LM, Jones, BC. Contemporary neurobehavioral genetics. Pharmacol Biochem Behav, 123, 1-2, 2014.
  5. Jones, BC, O'Callaghan, JP, Lu, L, Williams, RW, Alam, G, Miller, DB. Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains. Neurotoxicol Teratol, 45, 91-2, 2014.
  6. Jones, BC, Huang, X, Mailman, RB, Lu, L, Williams, RW. The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects. J Biochem Mol Toxicol, 28 (5), 191-7, 2014.
  7. Unger, EL, Jones, BC, Bianco, LE, Allen, RP, Earley, CJ. Diurnal variations in brain iron concentrations in BXD RI mice. Neuroscience, 263, 54-9, 2014.
  8. Jellen, LC, Lu, L, Wang, X, Unger, EL, Earley, CJ, Allen, RP, Williams, RW, Jones, BC. Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience, 252, 13-23, 2013.
  9. Jones, BC, Lu, L, Williams, RW, Unger, EL, Yin, L. Response to Breckenridge et al. (2013). Neurotoxicology, 38, 23-4, 2013.
  10. Unger, EL, Earley, CJ, Thomsen, LL, Jones, BC, Allen, RP. Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal. Neuroscience, 246, 179-85, 2013.
  11. Jones, BC, Miller, DB, O'Callaghan, JP, Lu, L, Unger, EL, Alam, G, Williams, RW. Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology, 37, 26-34, 2013.
  12. Yin, L, Unger, EL, Jellen, LC, Earley, CJ, Allen, RP, Tomaszewicz, A, Fleet, JC, Jones, BC. Systems genetic analysis of multivariate response to iron deficiency in mice. Am J Physiol Regul Integr Comp Physiol, 302 (11), R1282-96, 2012.
  13. Jellen, LC, Unger, EL, Lu, L, Williams, RW, Rousseau, S, Wang, X, Earley, CJ, Allen, RP, Miles, MF, Jones, BC. Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics, 13 (2), 147-57, 2012.
  14. Gibson, JN, Jellen, LC, Unger, EL, Morahan, G, Mehta, M, Earley, CJ, Allen, RP, Lu, L, Jones, BC. Genetic analysis of iron-deficiency effects on the mouse spleen. Mamm Genome, 22 (9-10), 556-62, 2011.
  15. Mohamed, WM, Ben Hamida, S, Cassel, JC, de Vasconcelos, AP, Jones, BC. MDMA: interactions with other psychoactive drugs. Pharmacol Biochem Behav, 99 (4), 759-74, 2011.
  16. Yin, L, Lu, L, Prasad, K, Richfield, EK, Unger, EL, Xu, J, Jones, BC. Genetic-based, differential susceptibility to paraquat neurotoxicity in mice. Neurotoxicol Teratol, 33 (3), 415-21, 2010.
  17. Jones, BC, Ben-Hamida, S, de Vasconcelos, AP, Kelche, C, Lazarus, C, Jackisch, R, Cassel, JC. Effects of ethanol and ecstasy on conditioned place preference in the rat. J Psychopharmacol, 24 (2), 275-9, 2010.
  18. Mohamed, WM, Hamida, SB, de Vasconcelos, AP, Cassel, JC, Jones, BC. Interactions between 3,4-methylenedioxymethamphetamine and ethanol in humans and rodents. Neuropsychobiology, 60 (3-4), 188-94, 2009.
  19. Jellen, LC, Beard, JL, Jones, BC. Systems genetics analysis of iron regulation in the brain. Biochimie, 91 (10), 1255-9, 2009.
  20. Jones, LC, Earley, CJ, Allen, RP, Jones, BC. Of mice and men, periodic limb movements and iron: how the human genome informs the mouse genome. Genes Brain Behav, 7 (5), 513-4, 2008.