Ajay J. Talati, MD

Sheldon B Korones Chair and Chief, Neonatology
Professor, Pediatrics and OB/GYN
Program Director, Neonatal-Perinatal Medicine fellowship

Office: E201 ROUT CENTER FOR WOMEN AND NEWBORNS
853 JEFFERSON AVENUE
MEMPHIS TN 381030000
Tel: (901) 448-5950
atalati@uthsc.edu

Research Interest/Specialty

Neonatal infections and antibiotic stewardship

Gut microbiome and alterations 

Clinical Care Specialty/Interest

Neonatal Intensive Care unit with special interest in quality improvement, neonatal sepsis

Publications

 

1.               Kabra S, Talati AJ, Shah R, Desai K, Modi RR: Acute acalculous cholecystitis. Indian Pediatrics 28:803-806, 1991.

 
2.               Talati AJ, Kabra S, Naik P, Bose P, Modi R: Histiocytosis X - Hand Schuller Christian Disease. Indian Practitioner XLV(1):67-70, 1992.

 
3.               Talati AJ, Naik P, Modi RR: Multiple congenital malformations following anti-tuberculous drugs in pregnancy. Indian Practitioner XLVI:6, 1993.

 
4.               Madhulika, Kabra SK, Talati AJ: Vitamin A supplementation in post-measles complications. Journal of Tropical Pediatrics 40(5):305-307, 1994.

 
5.               Kabra SK, Soni N, Talati AJ, Patel S, Mehta R, Shah R, Modi RR: Intrahepatic biliary dilatation with aortoarteritis. Indian Pediatrics 32(1):92-95, 1995.

 
6.               Talati AJ, Crouse DT, English BK, Newman C, Livingston L, Meals E:Exogenous bovine surfactant suppresses TNF alpha release by murine macrophages stimulated by genital mycoplasmas. Journal of Infectious Diseases 178:1122-1125, 1998.

 
7.               Haddad B, Mercer B, Livingston JC, Talati A, Sibai BM: Outcome after successful resuscitation of babies born with Apgar scores of 0 at both one and five minutes. American Journal of Obstetrics and Gynecology 182:1210-4, 2000.

 
8.               Talati AJ, Salim MA, Korones SB: Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn: A case report. American Journal of Perinatology 17(2): 69-71, 2000.

 
9.               Kabra SK, Madhulika, Talati A, Soni N: Multidrug-resistant typhoid fever. Tropical Doctor 30(4):195-197, 2000.

 
10.       Talati AJ, Crouse DT, English BK, Newman C, Harrison L, Meals E: Immunomodulation by exogenous surfactant: effect on TNF-a secretion and luminol-enhanced chemiluminescence activity by murine macrophages stimulated with group B streptococci. Microbes and Infection 3:1-7, 2001.

 
11.       Blackall DP, Liles LH, Talati A: In utero development of a warm-reactive autoantibody in a severely jaundiced neonate. Transfusion 42:44-47, 2002.
 

12.       Koneru P, Kaufman RA, Talati AJ, Jenkins MB, Korones SB: Successful treatment of sodium polystyrene sulfonate bezoars with serial water-soluble contrast enemas. Journal of Perinatology 23:431-433, 2003.
 

13.       Stovall SH, Yi A-K, Meals EA, Talati AJ, Godambe SA, English BK: Role of vav1- and src-related tyrosine kinases in macrophage activation by CpG DNA. Journal of Biological Chemistry 279:13809-13816, 2004.
 

14.       Brinkmann KC, Talati AJ, Akbari RA, Meals E, English BK: Group B streptococci exposed to Rifampin or Clindamycin (versus Ampicillin or Cefotaxime) stimulate reduced production of inflammatory mediators by murine macrophages. Pediatric Research 57: 419-423, 2005.
 

15.       Talati AJ, Yang W, Yolton K, Korones SB, Bada HS: Combination of early perinatal factors to identify neonates for neuroprotection. Journal of Perinatology (25): 245-50, 2005.
 

16.       English BK, Maryniw E, Talati AJ, Meals EA: Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin vs vancomycin or oxacillin. Antimicrobial agents and Chemotherapy, Antimicrob Agents Chemother. Jun;50(6):2225-7, 2006.
 

17.       James I. Hagadorn, Anne M. Furey, Tuyet-Hang Nghiem, Christopher H.
            Schmid, Dale L. Phelps, De-Ann M. Pillers, Cynthia H. Cole  and the AVIOx Study Group. Achieved Versus Intended Pulse Oximeter Saturation in Infants Born Less
            Than 28 Weeks'' Gestation: The AVIOx Study. Pediatrics 118 1574-1582, 2006.
 

18.       John V, Dai H, Talati A, Charnigo R, Neuman M, Bada HS: Autonomic Alterations in Cocaine-Exposed Neonates Following Orthostatic Stress. Pediatr Res. Feb; 61(2):251-6, 2007.
19.       Rouse DJ, Hirtz and the Eunice Kennedy Shriver Maternal-fetal Medicine Network Units: A randomized, controlled trial of Magnesium sulfate for the prevention of cerebral palsy, The New England Journal of Medicine, August; 359 (9): 895-905, 2008.

 
20.       Talati AJ, Kim H-J, Kim YI, Yi AK, English, BK: Role of bacterial DNA in macrophage activation by Group B streptococci, Microbes and Infection,10: 1106-1113, 2008

 
21.       Crumby T, Rinehart E, Carby M, Kuhl D, Talati AJ : Evaluation of Vancomycin First Dose Kinetics for Therapy Guidance in the Neonatal Intensive Care Unit, American Journal of Health-System Pharmacy, January; 66: 149-53, 2009.

 
22.       Thomas Spentzas, Ravi Kudumula, Carlos Acuna, Ajay J Talati, Kimberly Ingram, Fabio Savorgnan, Elizabeth A Meals and B.Keith English. Role of bacterial components in  macrophage activation by the LAC and MW2 strains of community-associated,         methicillin-resistant strains of Staphylococcus aureus. In print Cellular Immunology    (2011), doi: 10.1016/j.cellimm.2011.03.009

 
23.       Talati AJ and Koneru P.Neonates at risk for Congenital Syphilis: Radiographic and           Cerebrospinal fluid Evaluations. Southern Medical Journal, 2011; 104(12): 827-30

 
24.       Hasan M, Pourcyrous MP, Talati AJ. Bacillus cereus meningo-encephalitis with diabetes  insipidus in a preterm infant. Accepted for publication in Journal of Neonatal –Perinatal             Medicine, October 2011.   

 
25.       Ingram K, Marker M, Meals EA, Talati AJ, Spentzas T, English BK. Azithromycin inhibits macrophage tumor necrosis factor secretion in response to both azithromycin-susceptible and azithromycin-resistant pneumococci. Journal of Pediatric Infectious Diseases, accepted for publication, Jan 2013. 

 
26.       Elabaid MT, Harsono M, Talati AJ, Dhanireddy R. Effect of Birth Weight on the Association between Necrotizing Enterocolitis and Red Blood Cell Transfusions in ≤1500 g Infants BMJ Open 2013;3:e003823 doi:10.1136/bmjopen-2013-003823, PMID:24285632

 
27.       O. Dolapo, R. Dhanireddy, A. J. Talati, Trends of Staphylococcus aureus Bloodstream Infectionsin a Neonatal Intensive Care Unit from 2000-2009, BMC Pediatrics, 2014, 24886471, Reprinted in Neonatal Intensive Care, Sept 2014

 
28.       Dereddy, N, Talati AJ, Smith A, Kudumula R, Dhanireddy R. A Multipronged Approach            Is Associated with Improved Breast Milk Feeding Rates in Very Low Birth Weight Infants of an Inner-City Hospital, J Hum Lact. 2014 Oct 17. pii: 0890334414554619. [Epub ahead of print], PMID:25326415

Publications

  1. Mink, R, Schwartz, A, Carraccio, C, High, P, Dammann, C, McGann, KA, Kesselheim, J, Herman, B, ,. Creating the Subspecialty Pediatrics Investigator Network. J Pediatr, 192, 3-4.e2, 2018.
  2. Savani, M, Upadhyay, K, Talati, AJ. Characteristics and outcomes of very low birth weight infants receiving epinephrine during delivery room resuscitation. Resuscitation, 115, 1-4, 2017.
  3. Upadhyay, K, Park, JE, Yoon, TW, Halder, P, Kim, YI, Metcalfe, V, Talati, AJ, English, BK, Yi, AK. Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway. J Immunol, 198 (11), 4448-4457, 2017.
  4. Rana, D, Bellflower, B, Sahni, J, Kaplan, AJ, Owens, NT, Arrindell, EL, Talati, AJ, Dhanireddy, R. Reduced narcotic and sedative utilization in a NICU after implementation of pain management guidelines. J Perinatol, 2017.
  5. Thoni, N, Gaston, K, Talati, AJ. Choosing Wisely: Reduction of Antibiotic Use for Early-Onset Sepsis Prophylaxis in Neonates. Am J Med Qual, 32 (3), 338, 2017.
  6. Davidson, J, Polly, S, Hayes, PJ, Fisher, KR, Talati, AJ, Patel, T. Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate. AJP Rep, 7 (2), e134-e137, 2017.
  7. Upadhyay, K, Hiregoudar, B, Meals, E, English, BK, Talati, AJ. Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. PLoS One, 12 (7), e0182023, 2016.
  8. Dereddy, NR, Pivnick, EK, Upadhyay, K, Dhanireddy, R, Talati, AJ. Neonatal Hospital Course and Outcomes of Live-born Infants with Trisomy 18 at Two Tertiary Care Centers in the United States. Am J Perinatol, 2016.
  9. Shah, SD, Dereddy, N, Jones, TL, Dhanireddy, R, Talati, AJ. Early versus Delayed Human Milk Fortification in Very Low Birth Weight Infants-A Randomized Controlled Trial. J Pediatr, 174, 126-131.e1, 2016.
  10. Patel, S, Dereddy, N, Talati, AJ, Gaston, K, Dhanireddy, R. Glycerin Suppositories Use in Very Low Birth Weight Infants. Am J Perinatol, 2016.
  11. Gulati, R, Elabiad, MT, Talati, AJ, Dhanireddy, R. Trends in Medication Use in Very Low-Birth-Weight Infants in a Level 3 NICU over 2 Decades. Am J Perinatol, 33 (4), 370-7, 2016.
  12. Shah, SD, Talati, AJ, Elabiad, MT, Dhanireddy, R, Pourcyrous, M. Preterm Infants Can Mount Appropriate C-Reactive Protein Responses to Early Onset Sepsis. Am J Perinatol, 32 (13), 1281-6, 2015.
  13. Upadhyay, K, Pourcyrous, M, Dhanireddy, R, Talati, AJ. Outcomes of neonates with birth weight⩽500 g: a 20-year experience. J Perinatol, 35 (9), 768-72, 2015.
  14. Dereddy, NR, Talati, AJ, Smith, A, Kudumula, R, Dhanireddy, R. A multipronged approach is associated with improved breast milk feeding rates in very low birth weight infants of an inner-city hospital. J Hum Lact, 31 (1), 43-6, 2015.
  15. Ingram, K, Marker, M, Meals, E, Talati, AJ, Spentzas, T, English, BK. Azithromycin Inhibits Macrophage Tumor Necrosis Factor Secretion in Response to Both Azithromycin-Susceptible and Azithromycin-Resistant Pneumococci. J Pediatric Infect Dis Soc, 3 (2), 168-71, 2014.
  16. Elabiad, MT, Harsono, M, Talati, AJ, Dhanireddy, R. Effect of birth weight on the association between necrotising enterocolitis and red blood cell transfusions in <=1500 g infants. BMJ Open, 3 (11), e003823, 2013.
  17. Dolapo, O, Dhanireddy, R, Talati, AJ. Trends of Staphylococcus aureus bloodstream infections in a neonatal intensive care unit from 2000-2009. BMC Pediatr, 14, 121, 2013.
  18. Talati, AJ, Koneru, P. Neonates at risk for congenital syphilis: radiographic and cerebrospinal fluid evaluations. South Med J, 104 (12), 827-30, 2011.
  19. Spentzas, T, Kudumula, R, Acuna, C, Talati, AJ, Ingram, KC, Savorgnan, F, Meals, EA, English, BK. Role of bacterial components in macrophage activation by the LAC and MW2 strains of community-associated, methicillin-resistant Staphylococcus aureus. Cell Immunol, 269 (1), 46-53, 2010.
  20. Crumby, T, Rinehart, E, Carby, MC, Kuhl, D, Talati, AJ. Pharmacokinetic comparison of nomogram-based and individualized vancomycin regimens in neonates. Am J Health Syst Pharm, 66 (2), 149-53, 2009.
  21. Talati, AJ, Kim, HJ, Kim, YI, Yi, AK, English, BK. Role of bacterial DNA in macrophage activation by group B streptococci. Microbes Infect, 10 (10-11), 1106-13, 2007.
  22. English, BK, Maryniw, EM, Talati, AJ, Meals, EA. Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin. Antimicrob Agents Chemother, 50 (6), 2225-7, 2006.
  23. Talati, AJ, Yang, W, Yolton, K, Korones, SB, Bada, HS. Combination of early perinatal factors to identify near-term and term neonates for neuroprotection. J Perinatol, 25 (4), 245-50, 2005.
  24. Brinkmann, KC, Talati, AJ, Akbari, RE, Meals, EA, English, BK. Group B streptococci exposed to rifampin or clindamycin (versus ampicillin or cefotaxime) stimulate reduced production of inflammatory mediators by murine macrophages. Pediatr Res, 57 (3), 419-23, 2005.
  25. Stovall, SH, Yi, AK, Meals, EA, Talati, AJ, Godambe, SA, English, BK. Role of vav1- and src-related tyrosine kinases in macrophage activation by CpG DNA. J Biol Chem, 279 (14), 13809-16, 2004.
  26. Koneru, P, Kaufman, RA, Talati, AJ, Jenkins, MB, Korones, SB. Successful treatment of Sodium PolyStyrene Sulfonate bezoars with serial water-soluble contrast enemas. J Perinatol, 23 (5), 431-3, 2003.
  27. Blackall, DP, Liles, LH, Talati, AJ. In utero development of a warm-reactive autoantibody in a severely jaundiced neonate. Transfusion, 42 (1), 44-7, 2002.