ALEJANDRO M. DOPICO, M.D., Ph.D.

Professor and Chair
Pharmacology
 
Professor
Pharmaceutical Sciences

Office: 231 TRANSLATIONAL RESEARCH BUILDING
71 SOUTH MANASSAS
MEMPHIS TN 38163
Tel: (901) 448-3822
adopico@uthsc.edu

Education

  • UMassachusetts Medical, Worcester, MA, Electrophys./Vasc. Phys.
  • Ph.D., University of Buenos Aires, Argentina, Pharmacology
  • M.D., University of Buenos Aires, Argentina, Medicine
  • B.A., University of Buenos Aires, Argentina, Liberal Arts

Publications

  1. Dopico, AM, Lovinger, DM. Acute Alcohol Action and Desensitization of Ligand-Gated Ion Channels. Pharmacol Rev, 2009.
  2. Bukiya, AN, McMillan, J, Parrill, AL, Dopico, AM. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels. J Lipid Res, 49 (11), 2441-51, 2008.
  3. Liu, J, Vaithianathan, T, Manivannan, K, Parrill, A, Dopico, AM. Ethanol modulates BKCa channels by acting as an adjuvant of calcium. Mol Pharmacol, 74 (3), 628-40, 2008.
  4. Patil, S, Bukiya, AN, Li, W, Dopico, AM, Miller, D. Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels. Bioorg Med Chem Lett, 18 (11), 3427-30, 2008.
  5. Bukiya, AN, Vaithianathan, T, Toro, L, Dopico, AM. The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor. FEBS Lett, 582 (5), 673-8, 2008.
  6. Dopico, AM, Tigyi, GJ. A glance at the structural and functional diversity of membrane lipids. Methods Mol Biol, 400, 1-13, 2007.
  7. Cheng, X, Liu, J, Asuncion-Chin, M, Blaskova, E, Bannister, JP, Dopico, AM, Jaggar, JH. A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits. J Biol Chem, 282 (40), 29211-21, 2007.
  8. Bukiya, AN, Liu, J, Toro, L, Dopico, AM. Beta1 (KCNMB1) subunits mediate lithocholate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries. Mol Pharmacol, 72 (2), 359-69, 2007.
  9. Liu, J, Asuncion-Chin, M, Liu, P, Dopico, AM. CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. Nat Neurosci, 9 (1), 41-9, 2006.
  10. Jaggar, JH, Li, A, Parfenova, H, Liu, J, Umstot, ES, Dopico, AM, Leffler, CW. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res, 97 (8), 805-12, 2005.
  11. Liu, P, Xi, Q, Ahmed, A, Jaggar, JH, Dopico, AM. Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction. Proc Natl Acad Sci U S A, 101 (52), 18217-22, 2004.
  12. Liu, P, Liu, J, Huang, W, Li, MD, Dopico, AM. Distinct regions of the slo subunit determine differential BKCa channel responses to ethanol. Alcohol Clin Exp Res, 27 (10), 1640-4, 2003.
  13. Dopico, AM. Ethanol sensitivity of BK(Ca) channels from arterial smooth muscle does not require the presence of the beta 1-subunit. Am J Physiol Cell Physiol, 284 (6), C1468-80, 2003.
  14. Dopico, AM, Walsh, JV, Singer, JJ. Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells. J Gen Physiol, 119 (3), 251-73, 2002.