Ayotunde Dokun MD PhD

Associate Professor
Medicine- Endocrinology
Chief of Endocrine Service, Regional One Health

Office: STE 300 920 MADISON BUILDING
920 MADISON AVENUE
MEMPHIS TN 381632275
Tel: (901) 448-5318
adokun@uthsc.edu

Education

  • PostDoc, Duke University Medical Center, Research Focused Fellowship, Endocrinology and Metabolism
  • Other, Duke University Medical Center, Residency, Internal Medicine
  • Other, Duke University Medical Center, Internship
  • M.D., The Mount Sinai School of Medicine, New York, NY, Medicine
  • Ph.D., The Mount Sinai School of Medicine, New York, NY, Immunobiology
  • B.S., State University of New York, Long Island, NY, Biological Science
  • AAS, Bronx Community College, Pre-Pharmacy

Honors and Awards

2016 The Elijah B Saunders MD, Physician of the Year Award. National Medical Association, Internal Medicine Section.

2014 Translation Research Award, and Oral Presentation National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), Network of Minority Research Investigators (NMRI)

2013 Jay D. Coffman Early Career Investigator Award. American Heart Association (AHA) (National competitive award recognizes the research of an outstanding Peripheral Vascular Disease early career investigator at the Annual AHA scientific meeting)

2013 Clinical & Translational Research Award, Marco Cabrera Poster Session, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), Network of Minority Research Investigators (NMRI)

2011 Translation Research Award, Marco Cabrera Poster Session, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), Network of Minority Research Investigators (NMRI)

2009 Robert Wood Johnson Foundation, Medical Faculty Development Program Award. (This is a highly competitive national award with the goal of facilitating the transition of the newly-trained clinicians who wishes to develop into an independent investigator. Only 10-12 awards are given annually (2009-2013).

2008 National Institute of Health (NIH), National Medical Association (NMA Fellows in Academic Careers Program Competitive Travel Award. (Award provides funds to “select” residents or fellows for travel and accommodation to attend the annual meeting of NMA).

2003 Jeffrey Model Excellence in Research Award. Mt Sinai School of Medicine, New York, NY. (This is awarded annually to the graduate student with the most outstanding graduate thesis in Immunology).

2002 Doctoral Dissertation Award Mount Sinai School of Medicine, New York, NY. (This is awarded annually to the graduate student with the most outstanding graduate thesis in the graduating class. This is the highest award the institution awards to graduating students).

1994 National Research Service Award (NSRA) MARC Pre-doctoral Fellowship.

1991 Academic Achievement Award, SUNY, College at Old Westbury, L.I., NY.

1991 Excellence in Research Award, SUNY, College at Old Westbury, L.I,. NY.

1989 NIH Minority Access to Research Careers (MARC) Undergraduate Fellowship.

1988 National Institute of Health (NIH), Minority Biomedical Research Support Program.

1989 Academic Achievement Award, Bronx Community College, Bronx, NY.

1989 Unity and Strength Faculty Scholarship and Award, Bronx Com. Col., Bronx, NY

Clinical Care Specialty/Interest

 General Endocrinology, Diabetes, Obesity

Research Description

Previously we identified a genetic locus in mice that was associated with favorable recovery when present and its absence was associated with poor recovery following experimental PAD. We have been able to identify a number of genes within this locus that play a key role in vascular and skeletal muscle adaption to ischemia. Our team is currently disecting the molecular mechanisms of how these genes contribute to PAD and their role in poor PAD outcomes associated with diabetes.

Research Keywords

 Peripheral Arterial Disease, Vascular Complications, Vascular Disease, ADAM12, Angiogenesis, ischemia, VEGF, micro RNA

Research Interest/Specialty

My research interest is to understand the molecular mechanisms through which diabetes contributes to vascular disease using peripheral arterial disease as a model disease. Specifically I am interested in how specific metabolic abnormalities in diabetes such as hyperglycemia, hyperlipidemia and insulin resistance interact with genetic factors to modulate outcomes in PAD.

Publications

  1. Okeke, E, Dokun, AO. Role of genetics in peripheral arterial disease outcomes; significance of limb-salvage quantitative locus-1 genes. Exp Biol Med (Maywood), 243 (2), 190-197, 2018.
  2. McClung, JM, McCord, TJ, Ryan, TE, Schmidt, CA, Green, TD, Southerland, KW, Reinardy, JL, Mueller, SB, Venkatraman, TN, Lascola, CD, Keum, S, Marchuk, DA, Spangenburg, EE, Dokun, AO, Annex, BH, Kontos, CD. A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. Circulation, 2017.
  3. Chen, L, Okeke, E, Ayalew, D, Wang, D, Shahid, L, Dokun, AO.. Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia. Exp Biol Med, 14 (242), 1432-1443, 2017.
  4. Wang, T, Cunningham, A, Houston, K, Sharma, AM, Chen, L, Dokun, AO, Lye, RJ, Spolski, R, Leonard, WJ, Annex, BH. Endothelial interleukin-21 receptor up-regulation in peripheral artery disease. Vasc Med, 21 (2), 99-104, 2016.
  5. Ayotunde Dokun and Brian Annex.. Genetic and Genomics of Peripheral Arterial Disease. Editors: Willard HF and Ginsburg GS (Ed).. Genomic and Personalized Medicine Chapter Genomic and Personalized Medicine,, 1-, 2016.
  6. Dokun, AO, Chen, L, Okutsu, M, Farber, CR, Hazarika, S, Jones, WS, Craig, D, Marchuk, DA, Lye, RJ, Shah, SH, Annex, BH. ADAM12: a genetic modifier of preclinical peripheral arterial disease. Am J Physiol Heart Circ Physiol, 309 (5), H790-803, 2015.
  7. Wang, T, Cunningham, A, Dokun, AO, Hazarika, S, Houston, K, Chen, L, Lye, RJ, Spolski, R, Leonard, WJ, Annex, BH. Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia. Arterioscler Thromb Vasc Biol, 35 (5), 1218-25, 2015.
  8. Dokun, AO, Chen, L, Lanjewar, SS, Lye, RJ, Annex, BH. Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD. Cardiovasc Res, 101 (3), 364-72, 2014.
  9. Alexis Cunningham and Ayotunde O. Dokun. Update on Lessons Learned from Glycemic Control Studies.. Research Journal of health Science, 2 (3), 2014.
  10. Tao Wang, Alexis Cunningham, Ayotunde O Dokun, Surovi Hazarika Lingdan Chen, R. John Lye, Warren J. Leonard, Brian H Annex.. Angiogenic Properties of Interleukin-21 under Hypoxic Conditions.. Blood, 2014.
  11. Alexis Cunningham and Ayotunde O. Dokun.. MicroRNAs as Potential Therapeutic Targets in Peripheral Arterial Disease.. International Journal of Diabetology and Vascular Disease Research, 6 (2), 67-70, 2014.
  12. Imoukhuede, PI, Dokun, AO, Annex, BH, Popel, AS. Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia. Am J Physiol Heart Circ Physiol, 304 (8), H1085-93, 2013.
  13. Hazarika, S, Farber, CR, Dokun, AO, Pitsillides, AN, Wang, T, Lye, RJ, Annex, BH. MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway. Circulation, 127 (17), 1818-28, 2013.
  14. Ellati, RT, Dokun, AO, Kavoussi, PK, Steers, WD, Annex, BH, Lysiak, JJ. Increased phosphodiesterase type 5 levels in a mouse model of type 2 diabetes mellitus. J Sex Med, 10 (2), 362-9, 2013.
  15. Jones, WS, Duscha, BD, Robbins, JL, Duggan, NN, Regensteiner, JG, Kraus, WE, Hiatt, WR, Dokun, AO, Annex, BH. Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. Vasc Med, 17 (2), 94-100, 2012.
  16. Katwal A.B., Ayotunde O Dokun and Annex, B.H.. Genomics and molecular based therapy for peripheral arterial disease. Editors: Willard HF and Ginsburg GS (Ed).. Genomic and Personalized Medicine, 2nd Edition. Elsevier Publisher 2012 (chapter 57), 2012.
  17. Dokun, AO, Annex, BH. The VEGF165b "ICE-o-form" puts a chill on the VEGF story. Circ Res, 109 (3), 246-7, 2011.
  18. Katwal, AB, Dokun, AO. Peripheral arterial disease in diabetes: is there a role for genetics. Curr Diab Rep, 11 (3), 218-25, 2011.
  19. Dokun, AO. Lessons learned from glycemia control studies. Curr Diab Rep, 10 (2), 133-8, 2010.
  20. Dokun, AO, Keum, S, Hazarika, S, Li, Y, Lamonte, GM, Wheeler, F, Marchuk, DA, Annex, BH. A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation, 117 (9), 1207-15, 2008.
  21. Ayotunde O. Dokun and Brian Annex.. Genetic Polymorphisms in Peripheral Arterial Disease role of genomic methodologies. Editors: Hunt Willard and Geoffrey Ginsburg,. Genomic and Personalized Medicine, 2nd Edition. Elsevier Publisher, 1-2, 2008.
  22. Hazarika, S, Dokun, AO, Li, Y, Popel, AS, Kontos, CD, Annex, BH. Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. Circ Res, 101 (9), 948-56, 2007.
  23. Kim, S, Iizuka, K, Kang, HS, Dokun, A, French, AR, Greco, S, Yokoyama, WM. In vivo developmental stages in murine natural killer cell maturation. Nat Immunol, 3 (6), 523-8, 2002.
  24. Ayotunde O Dokun, Dortha T. Chu, Liping Yang, Albert S. Bendelac and Wayne M. Yokoyama.. Analysis of Natural Killer Cell Responses In situ during Viral Infection.. The Journal of Immunology, 167, 5287-5293, 2001.
  25. Ayotunde O Dokun, Sungjin Kim, Hamish H.R.C. Smith, Hyun-Seok P. Kang, Dortha T. Chu and Wayne M. Yokoyama.. Specific and Non-specific NK cell Activation During Virus Infection.. Nature Immunology, 10 (2), 951-956, 2001.
  26. Brown MG*, Ayotunde O Dokun*, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, Dubbelde CE, Stone LR, Scalzo AA, Yokoyama WM. *equal contributing first authors.. Vital involvement of a natural killer cell activation receptor in resistance to viral infection.. Science,, 5518 (292), 934-7, 2001.
  27. Lawrence L Wang, Dortha T. Chu, Ayotunde O. Dokun, Wayne M. Yokoyama.. Inducible expression of the gp49B inhibitory receptor on NK cells.. The Journal of Immunology,, 164, 5215-5220, 2000.
  28. Asch, A., Liu, I., Bricetti, F.M., Barnwell, J.W., Kwakye-Berko, F., Ayotunde O Dokun., Goldberger, J., and Pernambuco, M. .Analysis of CD36 binding domains: Ligand specificity controlled by dephosphorylation of an ectodomain.. Science, 262, 1993.
  29. Stefano, G.B. Cadet, P., Ayotunde O Dokun, and Scharrer, B.. A neuroimmunoregulatory-like mechanism reponding to stress in the marine bivalve Mollusk Mytilus edulis. Brain Behavior and Immunity, 4, 323-329, 1990.