ANDREW MICHAEL DAVIDOFF, M.D.

Professor
Surgery-General
 
Professor
Pathology

Office: 262 DANNY THOMAS PLACE MEMPHIS TN 381052794
Tel: (901) 595-4060
adavidof@uthsc.edu

Publications

  1. Rosati, SF, Williams, RF, Nunnally, LC, McGee, MC, Sims, TL, Tracey, L, Zhou, J, Fan, M, Ng, CY, Nathwani, AC, Stewart, CF, Pfeffer, LM, Davidoff, AM. IFN-{beta} sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Mol Cancer Ther, 2008.
  2. Sims, TL, Hamner, JB, Bush, RA, Williams, RF, Zhou, J, Kim, SU, Aboody, KS, Danks, MK, Davidoff, AM. Neural progenitor cell-mediated delivery of interferon beta improves neuroblastoma response to cyclophosphamide. Ann Surg Oncol, 15 (11), 3259-67, 2008.
  3. Sims, TL, Williams, RF, Ng, CY, Rosati, SF, Spence, Y, Davidoff, AM. Bevacizumab suppresses neuroblastoma progression in the setting of minimal disease. Surgery, 144 (2), 269-75, 2008.
  4. Dickson, PV, Sims, TL, Streck, CJ, McCarville, MB, Santana, VM, McGregor, LM, Furman, WL, Davidoff, AM. Avoiding misdiagnosing neuroblastoma as Wilms tumor. J Pediatr Surg, 43 (6), 1159-63, 2008.
  5. Davidoff, AM, Giel, DW, Jones, DP, Jenkins, JJ, Krasin, MJ, Hoffer, FA, Williams, MA, Dome, JS. The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer, 112 (9), 2060-70, 2008.
  6. Hamner, JB, Sims, TL, Cutshaw, A, Dickson, PV, Rosati, S, McGee, M, Ng, CY, Davidoff, AM. The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. J Pediatr Surg, 43 (1), 177-82; discussion 182-3, 2008.
  7. Gaillard, P, Krasin, MJ, Laningham, FH, Hoffer, FA, Davidoff, AM, Spunt, SL, Smiley, L, Skapek, SX. Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma. Pediatr Blood Cancer, 50 (1), 157-60, 2008.
  8. Gupta, H, Conrad, J, Khoury, JD, McGregor, LM, Krasin, MJ, Dome, JS, Santana, VM, Davidoff, AM. Significance of pleural effusion in neuroblastoma. Pediatr Blood Cancer, 49 (7), 906-8, 2007.
  9. Giel, DW, Williams, MA, Jones, DP, Davidoff, AM, Dome, JS. Renal function outcomes in patients treated with nephron sparing surgery for bilateral Wilms tumor. J Urol, 178 (4 Pt 2), 1786-9; discussion 1789-90, 2007.
  10. Saab, R, Khoury, JD, Krasin, M, Davidoff, AM, Navid, F. Desmoplastic small round cell tumor in childhood: the St. Jude Children's Research Hospital experience. Pediatr Blood Cancer, 49 (3), 274-9, 2007.
  11. Hamner, JB, Dickson, PV, Sims, TL, Zhou, J, Spence, Y, Ng, CY, Davidoff, AM. Bortezomib inhibits angiogenesis and reduces tumor burden in a murine model of neuroblastoma. Surgery, 142 (2), 185-91, 2007.
  12. Dickson, PV, Hamner, JB, Sims, TL, Fraga, CH, Ng, CY, Rajasekeran, S, Hagedorn, NL, McCarville, MB, Stewart, CF, Davidoff, AM. Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res, 13 (13), 3942-50, 2007.
  13. Dickson, PV, Hamner, B, Ng, CY, Hall, MM, Zhou, J, Hargrove, PW, McCarville, MB, Davidoff, AM. In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma. J Pediatr Surg, 42 (7), 1172-9, 2007.
  14. Gupta, H, Davidoff, AM, Pui, CH, Shochat, SJ, Sandlund, JT. Clinical implications and surgical management of intussusception in pediatric patients with Burkitt lymphoma. J Pediatr Surg, 42 (6), 998-1001; discussion 1001, 2007.
  15. Dickson, PV, Hamner, JB, Streck, CJ, Ng, CY, McCarville, MB, Calabrese, C, Gilbertson, RJ, Stewart, CF, Wilson, CM, Gaber, MW, Pfeffer, LM, Skapek, SX, Nathwani, AC, Davidoff, AM. Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature. Mol Cancer Res, 5 (6), 531-42, 2007.
  16. Gupta, H, Araki, Y, Davidoff, AM, Rao, BN, Hoffer, FA, Billups, C, Wu, J, Shochat, SJ. Evaluation of pediatric oncology patients with previous multiple central catheters for vascular access: is Doppler ultrasound needed. Pediatr Blood Cancer, 48 (5), 527-31, 2007.
  17. Nathwani, AC, Gray, JT, McIntosh, J, Ng, CY, Zhou, J, Spence, Y, Cochrane, M, Gray, E, Tuddenham, EG, Davidoff, AM. Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates. Blood, 109 (4), 1414-21, 2007.
  18. Benjamin, R, Khwaja, A, Singh, N, McIntosh, J, Meager, A, Wadhwa, M, Streck, C, Ng, C, Davidoff, AM, Nathwani, AC. Continuous delivery of human type I interferons (alpha/beta) has significant activity against acute myeloid leukemia cells in vitro and in a xenograft model. Blood, 109 (3), 1244-7, 2007.
  19. Dickson, PV, Hagedorn, NL, Hamner, JB, Fraga, CH, Ng, CY, Stewart, CF, Davidoff, AM. Interferon beta-mediated vessel stabilization improves delivery and efficacy of systemically administered topotecan in a murine neuroblastoma model. J Pediatr Surg, 42 (1), 160-5; discussion 165, 2007.
  20. Dickson, PV, Hamner, JB, Burger, RA, Garcia, E, Ouma, AA, Kim, SU, Ng, CY, Gray, JT, Aboody, KS, Danks, MK, Davidoff, AM. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg, 42 (1), 48-53, 2007.
  21. Krasin, MJ, Xiong, X, Reddick, WE, Ogg, RJ, Hoffer, FA, McCarville, B, Kaste, SC, Spunt, SL, Navid, F, Davidoff, AM, Zhang, L, Kun, LE, Merchant, TE. A model for quantitative changes in the magnetic resonance parameters of muscle in children after therapeutic irradiation. Magn Reson Imaging, 24 (10), 1319-24, 2006.
  22. Dickson, PV, Hamner, JB, Cauthen, LA, Ng, CY, McCarville, MB, Davidoff, AM. Efficacy of zoledronate against neuroblastoma. Surgery, 140 (2), 227-35, 2006.
  23. McCarville, MB, Streck, CJ, Dickson, PV, Li, CS, Nathwani, AC, Davidoff, AM. Angiogenesis inhibitors in a murine neuroblastoma model: quantitative assessment of intratumoral blood flow with contrast-enhanced gray-scale US. Radiology, 240 (1), 73-81, 2006.
  24. Gupta, H, Davidoff, AM, Rao, BN, Jenkins, JJ, Spunt, SL. Neonatal epithelioid sarcoma: a distinct clinical entity. J Pediatr Surg, 41 (7), e9-e11, 2006.
  25. Dickson, PV, Davidoff, AM. Malignant neoplasms of the head and neck. Semin Pediatr Surg, 15 (2), 92-8, 2006.
  26. McGregor, LM, Rao, BN, Davidoff, AM, Billups, CA, Hongeng, S, Santana, VM, Hill, DA, Fuller, C, Furman, WL. The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the St. Jude Children's Research Hospital Experience. Cancer, 104 (12), 2837-46, 2005.
  27. Streck, CJ, Ng, CY, Zhang, Y, Zhou, J, Nathwani, AC, Davidoff, AM. Interferon-mediated anti-angiogenic therapy for neuroblastoma. Cancer Lett, 228 (1-2), 163-70, 2005.
  28. Dickson, PV, Nathwani, AC, Davidoff, AM. Delivery of antiangiogenic agents for cancer gene therapy. Technol Cancer Res Treat, 4 (4), 331-41, 2005.
  29. Streck, CJ, Dickson, PV, Ng, CY, Zhou, J, Gray, JT, Nathwani, AC, Davidoff, AM. Adeno-associated virus vector-mediated systemic delivery of IFN-beta combined with low-dose cyclophosphamide affects tumor regression in murine neuroblastoma models. Clin Cancer Res, 11 (16), 6020-9, 2005.
  30. Krasin, MJ, Davidoff, AM, Rodriguez-Galindo, C, Billups, CA, Fuller, CE, Neel, MD, Merchant, TE. Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer, 104 (2), 367-73, 2005.
  31. Davidoff, AM, Gray, JT, Ng, CY, Zhang, Y, Zhou, J, Spence, Y, Bakar, Y, Nathwani, AC. Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models. Mol Ther, 11 (6), 875-88, 2005.
  32. Santana, VM, Furman, WL, Billups, CA, Hoffer, F, Davidoff, AM, Houghton, PJ, Stewart, CF. Improved response in high-risk neuroblastoma with protracted topotecan administration using a pharmacokinetically guided dosing approach. J Clin Oncol, 23 (18), 4039-47, 2005.
  33. Davidoff, AM, Ng, CY, Zhang, Y, Streck, CJ, Mabry, SJ, Barton, SH, Baudino, T, Zhou, J, Kerbel, RS, Vanin, EF, Nathwani, AC. Careful decoy receptor titering is required to inhibit tumor angiogenesis while avoiding adversely altering VEGF bioavailability. Mol Ther, 11 (2), 300-10, 2005.
  34. Davidoff, AM, Corey, BL, Hoffer, FA, Santana, VM, Furman, WL, Shochat, SJ. Radiographic assessment of resectability of locoregional disease in children with high-risk neuroblastoma during neoadjuvant chemotherapy. Pediatr Blood Cancer, 44 (2), 158-62, 2005.
  35. Streck, CJ, Zhang, Y, Zhou, J, Ng, C, Nathwani, AC, Davidoff, AM. Adeno-associated virus vector-mediated delivery of pigment epithelium-derived factor restricts neuroblastoma angiogenesis and growth. J Pediatr Surg, 40 (1), 236-43, 2005.
  36. Krasin, MJ, Rodriguez-Galindo, C, Billups, CA, Davidoff, AM, Neel, MD, Merchant, TE, Kun, LE. Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys, 60 (3), 830-8, 2004.
  37. Davidoff, AM, Ng, CY, Sleep, S, Gray, J, Azam, S, Zhao, Y, McIntosh, JH, Karimipoor, M, Nathwani, AC. Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock. J Virol Methods, 121 (2), 209-15, 2004.
  38. Krasin, MJ, Rodriguez-Galindo, C, Davidoff, AM, Billups, CA, Fuller, CE, Neel, MD, Kun, LE, Merchant, TE. Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors. Pediatr Blood Cancer, 43 (3), 229-36, 2004.
  39. Streck, CJ, Zhang, Y, Miyamoto, R, Zhou, J, Ng, CY, Nathwani, AC, Davidoff, AM. Restriction of neuroblastoma angiogenesis and growth by interferon-alpha/beta. Surgery, 136 (2), 183-9, 2004.
  40. Davidoff, AM, Nathwani, AC. Antiangiogenic gene therapy for cancer treatment. Curr Hematol Rep, 3 (4), 267-73, 2004.
  41. Streck, CJ, Zhou, J, Ng, CY, Zhang, Y, Nathwani, AC, Davidoff, AM. Longterm recombinant adeno-associated, virus-mediated, liver-generated expression of an angiogenesis inhibitor improves survival in mice with disseminated neuroblastoma. J Am Coll Surg, 199 (1), 78-86, 2004.
  42. Spurbeck, WW, Davidoff, AM, Lobe, TE, Rao, BN, Schropp, KP, Shochat, SJ. Minimally invasive surgery in pediatric cancer patients. Ann Surg Oncol, 11 (3), 340-3, 2004.
  43. Davidoff, AM, Kandel, JJ. Antiangiogenic therapy for the treatment of pediatric solid malignancies. Semin Pediatr Surg, 13 (1), 53-60, 2004.
  44. Gow, KW, Hayes-Jordan, AA, Billups, CA, Shenep, JL, Hoffer, FA, Davidoff, AM, Rao, BN, Schropp, KP, Shochat, SJ. Benefit of surgical resection of invasive pulmonary aspergillosis in pediatric patients undergoing treatment for malignancies and immunodeficiency syndromes. J Pediatr Surg, 38 (9), 1354-60, 2003.
  45. Davidoff, AM, Ng, CY, Zhou, J, Spence, Y, Nathwani, AC. Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway. Blood, 102 (2), 480-8, 2003.
  46. Spurbeck, WW, Ng, CY, Vanin, EF, Davidoff, AM. Retroviral vector-producer cell-mediated in vivo gene transfer of TIMP-3 restricts angiogenesis and neuroblastoma growth in mice. Cancer Gene Ther, 10 (3), 161-7, 2003.
  47. Wilson, MW, Moshfeghi, DM, Haik, BG, Haight, AE, Hill, DA, Davidoff, AM, Rousseau, RF, Bowman, LC. Occult orbital neuroblastoma detected after administration of an antitumor vaccine. Ophthal Plast Reconstr Surg, 19 (1), 77-9, 2003.
  48. Spurbeck, WW, Ng, CY, Strom, TS, Vanin, EF, Davidoff, AM. Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model. Blood, 100 (9), 3361-8, 2002.
  49. Chui, CH, Spunt, SL, Liu, T, Pappo, AS, Davidoff, AM, Rao, BN, Shochat, SJ. Is reexcision in pediatric nonrhabdomyosarcoma soft tissue sarcoma necessary after an initial unplanned resection. J Pediatr Surg, 37 (10), 1424-9, 2002.
  50. Davidoff, AM, Nathwani, AC, Spurbeck, WW, Ng, CY, Zhou, J, Vanin, EF. rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice. Cancer Res, 62 (11), 3077-83, 2002.
  51. Gow, KW, Dome, JS, Iglesias, J, Novick, WM, Hoffer, FA, Davidoff, AM. Intraatrial and intracaval Wilms' tumor. J Pediatr Surg, 36 (12), 1869-71, 2001.
  52. Davidoff, AM, Ng, CY, Brown, P, Leary, MA, Spurbeck, WW, Zhou, J, Horwitz, E, Vanin, EF, Nienhuis, AW. Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice. Clin Cancer Res, 7 (9), 2870-9, 2001.
  53. Davidoff, AM, Hill, DA. Molecular genetic aspects of solid tumors in childhood. Semin Pediatr Surg, 10 (3), 106-18, 2001.
  54. Davidoff, AM, Leary, MA, Ng, CY, Spurbeck, WW, Frare, P, Vanhove, M, Nienhuis, AW, Vanin, EF. Autocrine expression of both endostatin and green fluorescent protein provides a synergistic antitumor effect in a murine neuroblastoma model. Cancer Gene Ther, 8 (7), 537-45, 2001.
  55. Kogut, KA, Blakely, ML, Schropp, KP, Deselle, W, Hixson, SD, Davidoff, AM, Lobe, TE. The association of elevated percent bands on admission with failure and complications of interval appendectomy. J Pediatr Surg, 36 (1), 165-8, 2001.
  56. Davidoff, AM, Leary, MA, Ng, CY, Vanin, EF. Gene therapy-mediated expression by tumor cells of the angiogenesis inhibitor flk-1 results in inhibition of neuroblastoma growth in vivo. J Pediatr Surg, 36 (1), 30-6, 2001.
  57. Haight, AE, Bowman, LC, Ng, CY, Vanin, EF, Davidoff, AM. Humoral response to vaccination with interleukin-2-expressing allogeneic neuroblastoma cells after primary therapy. Med Pediatr Oncol, 35 (6), 712-5, 2000.
  58. Davidoff, AM, Leary, MA, Ng, CY, Vanin, EF. Retroviral vector-producer cell mediated angiogenesis inhibition restricts neuroblastoma growth in vivo. Med Pediatr Oncol, 35 (6), 638-40, 2000.
  59. Davidoff, AM, Kimbrough, SA, Ng, CY, Shochat, SJ, Vanin, EF. Neuroblastoma regression and immunity induced by transgenic expression of interleukin-12. J Pediatr Surg, 34 (5), 902-6; discussion 906-7, 1999.
  60. Davidoff, AM, Stevenson, SC, McClelland, A, Shochat, SJ, Vanin, EF. Enhanced neuroblastoma transduction for an improved antitumor vaccine. J Surg Res, 83 (2), 95-9, 1999.