ASTREINIDIS, ARISTOTELIS

Assistant Professor
Pediatrics

Office: 445R LE BONHEUR RESEARCH CENTER
50 NORTH DUNLAP STREET
MEMPHIS TN 381032893
Tel: (901) 287-5634
aastrein@uthsc.edu
http://www.astrinidislab.org/

Education

  • PostDoc, Fox Chase Cancer Center (Philadelphia, PA), Medical Oncology
  • Ph.D., Aristotle University of Thessaloniki (Greece), Biology
  • B.S., Aristotle University of Thessaloniki (Greece), Biology

Research Keywords

Tuberous Scleroris Complex (TSC), Lymphangioleiomyomatosis (LAM), mTOR, TSC1, TSC2, PLK1, mitosis, autophagy, cancer cell survival, combination therapy, laboratory mouse, pre-clinical drug testing

Publications

  1. Rajan, R, Karbowniczek, M, Pugsley, HR, Sabnani, MK, Astrinidis, A, La-Beck, NM. Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry. Cytometry A, 87 (5), 451-8, 2015.
  2. Valianou, M, Cox, AM, Pichette, B, Hartley, S, Paladhi, UR, Astrinidis, A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle, 14 (3), 399-407, 2015.
  3. Gómez-Baldó, L, Schmidt, S, Maxwell, CA, Bonifaci, N, Gabaldón, T, Vidalain, PO, Senapedis, W, Kletke, A, Rosing, M, Barnekow, A, Rottapel, R, Capellá, G, Vidal, M, Astrinidis, A, Piekorz, RP, Pujana, MA. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle, 9 (6), 1143-55, 2010.
  4. Astrinidis, A, Kim, J, Kelly, CM, Olofsson, BA, Torabi, B, Sorokina, EM, Azizkhan-Clifford, J. The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex. Genes Chromosomes Cancer, 49 (3), 282-97, 2010.
  5. Matthew, EM, Hart, LS, Astrinidis, A, Navaraj, A, Dolloff, NG, Dicker, DT, Henske, EP, El-Deiry, WS. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle, 8 (24), 4168-75, 2009.
  6. Yu, JJ, Robb, VA, Morrison, TA, Ariazi, EA, Karbowniczek, M, Astrinidis, A, Wang, C, Hernandez-Cuebas, L, Seeholzer, LF, Nicolas, E, Hensley, H, Jordan, VC, Walker, CL, Henske, EP. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci U S A, 106 (8), 2635-40, 2009.
  7. Astrinidis, A, Henske, EP. Mutation detection in tumor suppressor genes using archival tissue specimens. Methods Mol Med, 126, 185-96, 2006.
  8. Robb, VA, Astrinidis, A, Henske, EP. Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas. Mod Pathol, 19 (6), 839-46, 2006.
  9. Astrinidis, A, Senapedis, W, Henske, EP. Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Hum Mol Genet, 15 (2), 287-97, 2006.
  10. Astrinidis, A, Henske, EP. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene, 24 (50), 7475-81, 2005.
  11. Astrinidis, A, Henske, EP. Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex. J Child Neurol, 19 (9), 710-5, 2004.
  12. Karbowniczek, M, Cash, T, Cheung, M, Robertson, GP, Astrinidis, A, Henske, EP. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem, 279 (29), 29930-7, 2004.
  13. Yu, J, Astrinidis, A, Howard, S, Henske, EP. Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. Am J Physiol Lung Cell Mol Physiol, 286 (4), L694-700, 2004.
  14. Astrinidis, A, Senapedis, W, Coleman, TR, Henske, EP. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem, 278 (51), 51372-9, 2003.
  15. Karbowniczek, M, Astrinidis, A, Balsara, BR, Testa, JR, Lium, JH, Colby, TV, McCormack, FX, Henske, EP. Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med, 167 (7), 976-82, 2003.
  16. Astrinidis, A, Cash, TP, Hunter, DS, Walker, CL, Chernoff, J, Henske, EP. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene, 21 (55), 8470-6, 2002.