ADEBOWALE ADEBIYI, Ph.D.

Associate Professor

Office: C207 COLEMAN COLLEGE OF MEDICINE BUILDING
956 COURT AVENUE
MEMPHIS TN 381632116
Tel: (901) 448-1868
aadebiyi@uthsc.edu
http://physio1.uthsc.edu/~adebiyia/index.php

Education

  • PostDoc, University of Tennessee Health Science Center, Vascular Physiology
  • Ph.D., National University of Singapore, Singapore, Smooth Muscle Pharmacology
  • B.S., University of Lagos, Nigeria, Pharmacology

Research Keywords

Vascular smooth muscle cells, Renal hemodynamics, Glomerular mesangial cells, Ion channels

Research interest/specialty

My current research focuses primarily on elucidating signal transduction pathways in the kidney that are involved in the physiology and pathophysiology of renal hemodynamics. We utilize an integrative approach, including techniques drawn from cell and molecular biology, physiology, and pharmacology to investigate regulatory proteins, ion channels, and GPCRs that control renal vascular and glomerular functions.

Publications

  1. Soni, H, Adebiyi, A. TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways. Sci Rep, 6, 29041, 2016.
  2. Arora, K, Sinha, C, Zhang, W, Moon, CS, Ren, A, Yarlagadda, S, Dostmann, WR, Adebiyi, A, Haberman, Y, Denson, LA, Wang, X, Naren, AP. Altered cGMP dynamics at the plasma membrane contribute to diarrhea in ulcerative colitis. Am J Pathol, 185 (10), 2790-804, 2015.
  3. Kandasamy, K, Escue, R, Manna, J, Adebiyi, A, Parthasarathi, K. Changes in endothelial connexin 43 expression inversely correlate with microvessel permeability and VE-cadherin expression in endotoxin-challenged lungs. Am J Physiol Lung Cell Mol Physiol, 309 (6), L584-92, 2015.
  4. Soni H, Buddington RK, Adebiyi A.. Postnatal kidney maturation regulates renal artery myogenic constriction.. J Perinat Med, 43 (1), 119-22, 2015.
  5. Adebiyi, A, Soni, H, John, TA, Yang, F. Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells. Exp Cell Res, 324 (1), 92-104, 2014.
  6. Adebiyi, A. RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells. J Cell Physiol, 229 (4), 502-11, 2014.
  7. Soni, H, Adebiyi, A. Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs. J Endocrinol, 2013.
  8. Adebiyi, A, Thomas-Gatewood, CM, Leo, MD, Kidd, MW, Neeb, ZP, Jaggar, JH. An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension, 60 (5), 1213-9, 2012.
  9. Narayanan, D, Adebiyi, A, Jaggar, JH. Inositol trisphosphate receptors in smooth muscle cells. Am J Physiol Heart Circ Physiol, 302 (11), H2190-210, 2012.
  10. Thomas-Gatewood, C, Neeb, ZP, Bulley, S, Adebiyi, A, Bannister, JP, Leo, MD, Jaggar, JH. TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol, 301 (5), H1819-27, 2011.
  11. Adebiyi, A, McNally, EM, Jaggar, JH. Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol, 301 (4), H1360-8, 2011.
  12. Liang, GH, Adebiyi, A, Leo, MD, McNally, EM, Leffler, CW, Jaggar, JH. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. Am J Physiol Heart Circ Physiol, 300 (6), H2088-95, 2011.
  13. Bannister, JP, Thomas-Gatewood, CM, Neeb, ZP, Adebiyi, A, Cheng, X, Jaggar, JH. Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells. J Biol Chem, 286 (17), 15058-66, 2011.
  14. Adebiyi, A, Narayanan, D, Jaggar, JH. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. J Biol Chem, 286 (6), 4341-8, 2011.
  15. Zhao, G, Neeb, ZP, Leo, MD, Pachuau, J, Adebiyi, A, Ouyang, K, Chen, J, Jaggar, JH. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol, 136 (3), 283-91, 2010.
  16. Adebiyi, A, Zhao, G, Narayanan, D, Thomas-Gatewood, CM, Bannister, JP, Jaggar, JH. Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility. Circ Res, 106 (10), 1603-12, 2010.
  17. Bannister, JP, Adebiyi, A, Zhao, G, Narayanan, D, Thomas, CM, Feng, JY, Jaggar, JH. Smooth Muscle Cell {alpha}2{delta}-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels. Circ Res, 2009.
  18. Zhao, G, Adebiyi, A, Blaskova, E, Xi, Q, Jaggar, JH. Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries. Am J Physiol Cell Physiol, 295 (5), C1376-84, 2008.
  19. Adebiyi, A, McNally, EM, Jaggar, JH. Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Mol Pharmacol, 74 (3), 736-43, 2008.
  20. Xi, Q, Adebiyi, A, Zhao, G, Chapman, KE, Waters, CM, Hassid, A, Jaggar, JH. IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release. Circ Res, 102 (9), 1118-26, 2008.
  21. Zhao, G, Adebiyi, A, Xi, Q, Jaggar, JH. Hypoxia reduces KCa channel activity by inducing Ca2+ spark uncoupling in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol, 292 (6), C2122-8, 2007.
  22. Adebiyi, A, Zhao, G, Cheranov, SY, Ahmed, A, Jaggar, JH. Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am J Physiol Heart Circ Physiol, 292 (3), H1584-92, 2007.
  23. Li, A, Adebiyi, A, Leffler, CW, Jaggar, JH. KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol, 291 (3), H1118-25, 2006.
  24. Adebiyi, A, Adaikan, PG. Modulation of jejunal contractions by extract of Carica papaya L. seeds. Phytother Res, 19 (7), 628-32, 2005.
  25. Adaikan PG, Adebiyi A. Effect of functional modulation of Ca2+-activated Cl- currents on gravid rat myometrial activity. Indian J Pharmacol, 37 (1), 21-25, 2005.
  26. Adaikan, PG, Adebiyi, A.. Mechanisms of the oxytocic activity of papaya proteinases. Pharmaceutical Biology, 42 (8), 646 - 655, 2005.
  27. Adebiyi, A, Adaikan, PG, Prasad, RN. Effect of benzyl isothiocyanate on spontaneous and induced force of rat uterine contraction. Pharmacol Res, 49 (5), 415-22, 2004.
  28. Adebiyi, A, Adaikan, PG, Prasad, RN. Pregnancy outcomes following pre- and post-implantation exposure of Sprague-Dawley rats to benzyl isothiocyanate. Food Chem Toxicol, 42 (5), 715-20, 2004.
  29. Adebiyi, A, Adaikan, GP, Prasad, RN. Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists. J Perinat Med, 32 (2), 126-31, 2004.
  30. Adebiyi, A, Adaikan, PG. Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical stimulation. Clin Exp Pharmacol Physiol, 31 (1-2), 82-5, 2004.
  31. Adebiyi, A, Adaikan, PG, Prasad, RN. Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips. Phytomedicine, 11 (1), 65-70, 2004.
  32. Adebiyi, A, Ganesan Adaikan, P, Prasad, RN. Tocolytic and toxic activity of papaya seed extract on isolated rat uterus. Life Sci, 74 (5), 581-92, 2003.
  33. Adebiyi A, Prasad RN, Adaikan PG.. Effect of polyphloretin phosphate on the response of non-gravid rat uterus to folkloric and standard oxytocics in vitro.. Prostaglandins Leukot Essent Fatty Acids., 66 (5-6), 499-503., 2002.