Tao L. Lowe, Ph.D.
448 Pharmacy Building
- PostDoc, University of Wisconsin, Madison, Chemical Engineering
- Ph.D., University of Helsinki, Finland, Polymer Chemistry
Honors and Awards
Senior Member, American Institute of Chemical Engineers, 2011
Chair Elected, Biomaterials Area, American Institute of Chemical Engineers, 2009-2010
Early Career Award in Translational Research, Wallace H. Coulter Foundation, 2005
CIMO Graduate Fellowship, Finnish Ministry of Education and Culture, 1995-1998
In Dr. Lowe’s state-of-the-art “Biomaterials for Translational Research Laboratory”, the research features innovative bionanotechnology, drug delivery, gene therapy, tissue engineering, and biosensor. The research activities include rational design and synthesis of multi-stimuli-responsive polymeric biomaterials including nanogels, branched nanoparticles, hydrogels and thin films; characterizations of the mechanisms by which the designed biopolymers regulate targeted and sustained delivery of drugs, proteins and genes, promote cell growth, and provide biosensing; and in vitro and in vivo studies of the bioefficacy of these biomaterials. The ultimate goal of the research in Dr. Lowe’s lab is to develop novel biomaterials that can provide exquisitely sensitive, selective, non-toxic, biodegradable and responsive platforms to target therapeutic agents to the sites of ocular, central nervous, cancerous and musculoskeletal lesions.
- Misra, GP, Singh, RS, Aleman, TS, Jacobson, SG, Gardner, TW, Lowe, TL. Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. Biomaterials, 30 (33), 6541-7, 2009.
- Gil, ES, Li, J, Xiao, H, Lowe, TL. Quaternary ammonium beta-cyclodextrin nanoparticles for enhancing doxorubicin permeability across the in vitro blood-brain barrier. Biomacromolecules, 10 (3), 505-16, 2009.
- Stover, TC, Kim, YS, Lowe, TL, Kester, M. Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug. Biomaterials, 29 (3), 359-69, 2008.
- Huang, X, Zhang, Y, Donahue, HJ, Lowe, TL. Porous thermoresponsive-co-biodegradable hydrogels as tissue-engineering scaffolds for 3-dimensional in vitro culture of chondrocytes. Tissue Eng, 13 (11), 2645-52, 2007.
- Huang, X, Lowe, TL. Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs. Biomacromolecules, 6 (4), 2131-9, 2005.