Tao L. Lowe, Ph.D.

Associate Professor
Pharmaceutical Sciences
 
Associate Professor
Biomedical Engineering

Office: 448 COLLEGE OF PHARMACY BUILDING
881 MADISON AVENUE
MEMPHIS TN 381632198
Tel: (901) 448-1087
tlowe4@uthsc.edu
https://lowe.lab.uthsc.edu/

Education

  • PostDoc, University of Wisconsin, Madison, Chemical Engineering
  • Ph.D., University of Helsinki, Finland, Polymer Chemistry

Research Interest

In Dr. Lowe’s state-of-the-art “Biomaterials for Translational Research Laboratory”, the research features innovative nanotechnology, drug and gene delivery, regenerative medicine, precision medicine, neural engineering, stem cell engineering, contraception, and biosensoring. The research activities include rational design and synthesis of multi-stimuli-responsive polymeric biomaterials including nanogels, branched nanoparticles, hydrogels, in situ forming depots, and thin films, etc.; characterizations of the mechanisms by which the designed biomaterials regulate targeted and sustained delivery of drugs, proteins and genes, and promote cell growth; and in vitro and in vivo evaluations of the bioefficacy of these biomaterials. The ultimate goal of the research in Dr. Lowe’s lab is to develop novel biomaterials that can provide exquisitely sensitive, selective, non-toxic, biodegradable and responsive platforms to target therapeutic agents to the sites of ocular, central nervous, cancerous, alveolar, or musculoskeletal lesions.

Publications

  1. Janagam DR, Ananthula, S, Chaudhry K, Wu LF, Mandrell TD, Johnson JR and Lowe TL. Injectable In Situ Forming Depot Systems for Long-Acting Contraception. Advanced Biosystems, Online, August 25, 2017.
  2. Janagam DR, Wu LF and Lowe TL. Nanoparticles for Drug Delivery to the Anterior Segment of the Eye. Advanced Drug Delivery Review, Online, April 6, 2017.
  3. Imai H, Misra GP, Wu LF, Janagam DR, Gardner TW and Lowe TL. Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats. Investigative Ophthalmology & Visual Science (56), 7839-7846, 2015.
  4. Ananthula, S, Janagam DR, Jamalapurama S, Johnson JR, Mandrell TD and Lowe TL. Development and Validation of Sensitive LC/MS/MS Method for Quantitative Bioanalysis of Levonorgestrel in Rat Plasma and Application to Pharmacokinetics Study. Journal of Chromatography B (1003), 47–53, 2015.
  5. Gil ES, Wu LF, Xu LC and Lowe TL. β-Cyclodextrin-poly(β-Amino Ester) Nanoparticles for Sustained Drug Delivery across the Blood-Brain Barrier. Biomacromolecules, 11 (13), 3533-3541, 2012.
  6. Misra, GP, Singh, RS, Aleman, TS, Jacobson, SG, Gardner, TW, Lowe, TL. Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. Biomaterials, 30 (33), 6541-7, 2009.
  7. Gil, ES, Li, J, Xiao, H, Lowe, TL. Quaternary ammonium beta-cyclodextrin nanoparticles for enhancing doxorubicin permeability across the in vitro blood-brain barrier. Biomacromolecules, 10 (3), 505-16, 2009.
  8. Stover, TC, Kim, YS, Lowe, TL, Kester, M. Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug. Biomaterials, 29 (3), 359-69, 2008.
  9. Huang, X, Zhang, Y, Donahue, HJ, Lowe, TL. Porous thermoresponsive-co-biodegradable hydrogels as tissue-engineering scaffolds for 3-dimensional in vitro culture of chondrocytes. Tissue Eng, 13 (11), 2645-52, 2007.
  10. Huang, X, Lowe, TL. Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs. Biomacromolecules, 6 (4), 2131-9, 2005.